Cardiorespiratory fitness, atrial fibrillation and stroke: a review of the evidence in 2024

SK Kunutsor, S Kurl, JA Laukkanen - Expert Review of …, 2024 - Taylor & Francis
Introduction The body of evidence linking cardiorespiratory fitness (CRF) levels with the risk
of atrial fibrillation (AF) and stroke–two interconnected cardiovascular conditions–is not …

Atrial fibrillation versus. atrial myopathy in thrombogenesis: Two sides of the same coin?

PE Papakonstantinou, JM Rivera-Caravaca… - Trends in …, 2025 - Elsevier
Atrial fibrillation (AF) and atrial myopathy are recognized contributors to cardiovascular
morbidity, particularly ischemic stroke. AF poses an elevated risk of thrombogenesis due to …

Predicting Atrial Fibrillation After Stroke by Combining Polygenic Risk Scores and Clinical Features

RWP Tack, BYQ Tan, JR Senff, S Prapiadou… - Stroke, 2025 - ahajournals.org
Background: Since treatment with anticoagulants can prevent recurrent strokes,
identification of patients at risk for incident AF after stroke is crucial. We aimed to investigate …

Rethinking Stroke Prevention in Atrial Fibrillation: One Size Does not Fit All

PE Papakonstantinou, GYH Lip - Journal of Cardiovascular …, 2025 - Wiley Online Library
The cornerstone of stroke prevention in atrial fibrillation (AF) lies in thromboembolic risk
stratification, typically assessed through simple clinical risk scoring systems such as the …

Genetic Testing in Atrial Fibrillation Patients: Potential to Enhance Clinical Outcome Prediction

MS Olesen - Clinical Electrophysiology, 2024 - jacc.org
Atrial fibrillation (AF) is one of the most prevalent cardiac arrhythmias, associated with an
increased risk of heart failure, stroke, and premature death. Despite considerable advances …

Variant effects depend on polygenic background: experimental, clinical, and evolutionary implications

ME Chapel, J Dennis, CG de Boer - bioRxiv, 2025 - biorxiv.org
Both rare and common genetic variants contribute to human disease, and emerging
evidence suggests that they combine additively to influence disease liability. However, due …