The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication
delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from …

Three different barriers are formed between the cerebrovascular and the brain parenchyma:
the blood-brain barrier (BBB), the blood-cerebrospinal fluid barrier (BCSFB), and the …

The human vascular system, comprising endothelial (EC) and mural cells, covers a vast
surface area in the body, providing a critical interface between blood and tissue …

The blood-brain-barrier (BBB) has a major function in maintaining brain homeostasis by
regulating the entry of molecules from the blood to the brain. Key players in BBB function are …

Drug transporters play an important role in the maintenance of chemical balance and
homeostasis in different tissues. In addition to their physiological functions, they are crucial …

Uptake drug transporters play a significant role in the pharmacokinetic of drugs within the
brain, facilitating their entry into the central nervous system (CNS). Understanding brain drug …

Focused ultrasound in combination with microbubbles (FUS) provides an effective means to
locally enhance the delivery of therapeutics to the brain. Translational and quantitative …

One of the greatest challenges with successful pharmaceutical treatments of central nervous
system (CNS) diseases is the delivery of drugs into their target sites with appropriate …

Alzheimer's disease (AD) is the most common form of neurodegenerative disease. The
predominant characteristics of AD are the accumulation of amyloid-β (Aβ) and …

The blood-brain barrier (BBB) is a critical interface separating the central nervous system
from the peripheral circulation, ensuring brain homeostasis and function. Recent research …