Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
Progranulin as a therapeutic target in neurodegenerative diseases
Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development,
survival, function, and maintenance of neurons and microglia in the mammalian brain. It …
survival, function, and maintenance of neurons and microglia in the mammalian brain. It …
[HTML][HTML] Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity
Summary Apolipoprotein E4 (APOE4) is the greatest known genetic risk factor for
develo** sporadic Alzheimer's disease. How the interaction of APOE4 microglia with …
develo** sporadic Alzheimer's disease. How the interaction of APOE4 microglia with …
The metal ion hypothesis of Alzheimer's disease and the anti-neuroinflammatory effect of metal chelators
Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …
[HTML][HTML] Apolipoprotein E in lipid metabolism and neurodegenerative disease
LG Yang, ZM March, RA Stephenson… - Trends in Endocrinology & …, 2023 - cell.com
Dysregulation of lipid metabolism has emerged as a central component of many
neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E …
neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E …
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Abstract Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …
Cholesterol metabolism and homeostasis in the brain
Cholesterol is an essential component for neuronal physiology not only during development
stage but also in the adult life. Cholesterol metabolism in brain is independent from that in …
stage but also in the adult life. Cholesterol metabolism in brain is independent from that in …
Brain cell type-specific cholesterol metabolism and implications for learning and memory
Cholesterol homeostasis is vital for brain function. Brain cholesterol is locally synthesized,
with varying synthesis capacities across different cell types. Moreover, brain cholesterol …
with varying synthesis capacities across different cell types. Moreover, brain cholesterol …
LRP1 is a neuronal receptor for α-synuclein uptake and spread
Background The aggregation and spread of α-synuclein (α-Syn) protein and related
neuronal toxicity are the key pathological features of Parkinson's disease (PD) and Lewy …
neuronal toxicity are the key pathological features of Parkinson's disease (PD) and Lewy …
Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies: Thematic Review Series: ApoE and Lipid Homeostasis in …
Among the LDL receptor (LDLR) family members, the roles of LDLR-related protein (LRP) 1
in the pathogenesis of Alzheimer's disease (AD), especially late-onset AD, have been the …
in the pathogenesis of Alzheimer's disease (AD), especially late-onset AD, have been the …