Immunostimulatory antibody conjugates (ISACs) as a promising new generation of targeted
therapeutic antibody-drug conjugates (ADCs), that not only activate innate immunity but also …

Opinion statement Melanoma is one of the deadliest malignancies. Its incidence has been
significantly increasing in most countries in recent decades. Acral melanoma (AM), a …

Acral and mucosal melanoma are uncommon variants of melanoma. Acral melanoma has
an age-adjusted incidence of approximately 1.8 cases per million individuals per year …

Simple Summary Tumor-associated M2 macrophages impair the anti-tumor immune
response and negatively impact clinical outcomes. Hence, a strategy that eradicates these …

Different therapeutic strategies have been investigated to target and eliminate HIV-1-
infected cells by using armed antibodies specific to viral proteins, with varying degrees of …

Purpose Triple-negative breast cancer (TNBC) is phenotypic of breast tumors lacking
expression of the estrogen receptor (ER), the progesterone receptor (PgR), and the human …

Abstract Radiotherapy (RT), unlike chemotherapy, is one of the most routinely used and
effective genotoxic and immune response inducing cancer therapies with an advantage of …

Triple-negative breast cancer (TNBC) is the deadliest form of breast cancer with limited
treatment options. The persistence of highly tumorigenic CD44-expressing subpopulation …

Electrochemotherapy (ECT) involves locally applying electrical pulses to permeabilize cell
membranes, using electroporation (EP). This process enhances the uptake of low-permeant …

Simple Summary In this literature review, we explore the milestone events from the
discovery of BRAF mutations to present-day clinical intervention strategies. We delve into …