Species-Wide Transposable Element Repertoires Retrace the Evolutionary History of the Saccharomyces cerevisiae Host

C Bleykasten-Grosshans, R Fabrizio… - Molecular Biology …, 2021 - academic.oup.com
Transposable elements (TE) are an important source of genetic variation with a dynamic and
content that greatly differ in a wide range of species. The origin of the intraspecific content …

Structure of a Ty1 restriction factor reveals the molecular basis of transposition copy number control

MA Cottee, SL Beckwith, SC Letham, SJ Kim… - Nature …, 2021 - nature.com
Excessive replication of Saccharomyces cerevisiae Ty1 retrotransposons is regulated by
Copy Number Control, a process requiring the p22/p18 protein produced from a sub …

The Ty1 retrotransposon harbors a DNA region that performs dual functions as both a gene silencing and chromatin insulator

H Masumoto, H Muto, K Yano, Y Kurosaki, H Niki - Scientific Reports, 2024 - nature.com
In various eukaryotic kingdoms, long terminal repeat (LTR) retrotransposons repress
transcription by infiltrating heterochromatin generated within their elements. In contrast, the …

RNAthor–fast, accurate normalization, visualization and statistical analysis of RNA probing data resolved by capillary electrophoresis

J Gumna, T Zok, K Figurski, K Pachulska-Wieczorek… - PloS One, 2020 - journals.plos.org
RNAs adopt specific structures to perform their functions, which are critical to fundamental
cellular processes. For decades, these structures have been determined and modeled with …

Retroviral-like determinants and functions required for dimerization of Ty1 retrotransposon RNA

J Gumna, KJ Purzycka, HW Ahn, DJ Garfinkel… - RNA biology, 2019 - Taylor & Francis
During replication of long terminal repeat (LTR)-retrotransposons, their proteins and
genome (g) RNA assemble into virus-like particles (VLPs) that are not infectious but …

In vivo structure of the Ty1 retrotransposon RNA genome

A Andrzejewska, M Zawadzka, J Gumna… - Nucleic acids …, 2021 - academic.oup.com
Long terminal repeat (LTR)-retrotransposons constitute a significant part of eukaryotic
genomes and influence their function and evolution. Like other RNA viruses, LTR …

Cell compartment-specific folding of Ty1 long terminal repeat retrotransposon RNA genome

M Zawadzka, A Andrzejewska-Romanowska, J Gumna… - Viruses, 2022 - mdpi.com
The structural transitions RNAs undergo during trafficking are not well understood. Here, we
used the well-developed yeast Ty1 retrotransposon to provide the first structural model of …

RNA binding properties of the Ty1 LTR-retrotransposon Gag protein

J Gumna, A Andrzejewska-Romanowska… - International Journal of …, 2021 - mdpi.com
A universal feature of retroelement propagation is the formation of distinct nucleoprotein
complexes mediated by the Gag capsid protein. The Ty1 retrotransposon Gag protein from …

New windows into retroviral RNA structures

D Jayaraman, JC Kenyon - Retrovirology, 2018 - Springer
Background The multiple roles of both viral and cellular RNAs have become increasingly
apparent in recent years, and techniques to model them have become significantly more …

[PDF][PDF] Discovery of a novel restriction factor encoded by the retrotransposon ty1 in saccharomyces cerevisiae

A Saha - 2017 - getd.libs.uga.edu
Ty1 is the most active long terminal repeat (LTR) retrotransposon in Saccharomyces
cerevisiae and resembles retroviruses in genome organization and replication mechanisms …