Retinoblastoma is a rare cancer of the infant retina that is diagnosed in approximately 8,000
children each year worldwide. It forms when both retinoblastoma gene (RB1) alleles are …

Enhanced and deregulated expression of N-MYC, a member of the MYC family of
transcription factors, drives the development of multiple tumors, including tumors of the …

Retinoblastoma is a childhood cancer of the develo** retina that initiates with biallelic
inactivation of the RB1 gene. Children with germline mutations in RB1 have a high …

Retinoblastoma is the most frequent intraocular malignancy in children, originating from a
maturing cone precursor in the develo** retina. Little is known on the molecular basis …

Herein we provide a detailed molecular analysis of the spatial heterogeneity of clinically
localized, multifocal prostate cancer to delineate new oncogenes or tumor suppressors. We …

Retinoblastoma (Rb) is the most common primary intraocular malignancy of childhood, but
an uncommon paediatric cancer, with a constant incidence worldwide of 1: 15,000–1 …

The spectrum of tumours arising in childhood is fundamentally different from that seen in
adults, and they are known to be divergent from adult malignancies in terms of cellular …

Retinoblastoma (RB) is the most common intraocular malignancy in childhood.
Approximately 40% of retinoblastomas are hereditary and due to germline mutations in the …

Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to
preserve life, with ocular survival, visual preservation and quality of life as secondary aims …

The pediatric ocular cancer retinoblastoma is the only central nervous system (CNS) tumor
readily observed without specialized equipment: it can be seen by, and in, the naked eye …