Retinoblastoma Origins and Destinations | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …

Retinoblastoma is a rare cancer of the infant retina that is diagnosed in approximately 8,000
children each year worldwide. It forms when both retinoblastoma gene (RB1) alleles are …

Retinoblastoma (Rb), the most frequent malignant intraocular tumor in childhood, is caused
by mutations in the retinoblastoma gene (RB1) situated on chromosome 13q14. 2. The …

Herein we provide a detailed molecular analysis of the spatial heterogeneity of clinically
localized, multifocal prostate cancer to delineate new oncogenes or tumor suppressors. We …

Enhanced and deregulated expression of N-MYC, a member of the MYC family of
transcription factors, drives the development of multiple tumors, including tumors of the …

With an average incidence of 1 in every 18,000 live births, retinoblastoma is a rare type of
intraocular tumour found to affect patients during their early childhood. It is curable if …

Retinoblastoma (Rb) is the most common primary intraocular malignancy of childhood, but
an uncommon paediatric cancer, with a constant incidence worldwide of 1: 15,000–1 …

Retinoblastoma is a childhood cancer of the develo** retina that initiates with biallelic
inactivation of the RB1 gene. Children with germline mutations in RB1 have a high …

The spectrum of tumours arising in childhood is fundamentally different from that seen in
adults, and they are known to be divergent from adult malignancies in terms of cellular …

Importance Early diagnosis of retinoblastoma, the most common intraocular cancer, can
save both a child's life and vision. However, anecdotal evidence suggests that many …