Structure and function of haemoglobins
DA Gell - Blood Cells, Molecules, and Diseases, 2018 - Elsevier
Haemoglobin (Hb) is widely known as the iron-containing protein in blood that is essential
for O 2 transport in mammals. Less widely recognised is that erythrocyte Hb belongs to a …
for O 2 transport in mammals. Less widely recognised is that erythrocyte Hb belongs to a …
From hemoglobin allostery to hemoglobin-based oxygen carriers
Hemoglobin (Hb) plays its vital role through structural and functional properties
evolutionarily optimized to work within red blood cells, ie, the tetrameric assembly, well …
evolutionarily optimized to work within red blood cells, ie, the tetrameric assembly, well …
A tertiary two-state allosteric model for hemoglobin
The two-state allosteric model of Monod, Wyman, and Changeux (MWC) provides an
excellent description of homotropic effects in a vast array of equilibrium and kinetic …
excellent description of homotropic effects in a vast array of equilibrium and kinetic …
Evolution of allosteric models for hemoglobin
We compare various allosteric models that have been proposed to explain cooperative
oxygen binding to hemoglobin, including the two‐state allosteric model of Monod, Wyman …
oxygen binding to hemoglobin, including the two‐state allosteric model of Monod, Wyman …
New insights into allosteric mechanisms from trap** unstable protein conformations in silica gels
To understand why the classical two-state allosteric model of Monod, Wyman, and
Changeux explains cooperative oxygen binding by hemoglobin but does not explain …
Changeux explains cooperative oxygen binding by hemoglobin but does not explain …
Exploring and exploiting allostery: Models, evolution, and drug targeting
The concept of allostery was elaborated almost 50years ago by Monod and coworkers to
provide a framework for interpreting experimental studies on the regulation of protein …
provide a framework for interpreting experimental studies on the regulation of protein …
Experimental basis for a new allosteric model for multisubunit proteins
Monod, Wyman, and Changeux (MWC) explained allostery in multisubunit proteins with a
widely applied theoretical model in which binding of small molecules, so-called allosteric …
widely applied theoretical model in which binding of small molecules, so-called allosteric …
Structural basis of sequential and concerted cooperativity
Allostery is a property of biological macromolecules featuring cooperative ligand binding
and regulation of ligand affinity by effectors. The definition was introduced by Monod and …
and regulation of ligand affinity by effectors. The definition was introduced by Monod and …
Allosteric transitions in hemoglobin revisited
N Shibayama - Biochimica et Biophysica Acta (BBA)-General Subjects, 2020 - Elsevier
Background Human hemoglobin is an allosteric protein that exerts exquisite control over
ligand binding through large-scale conformational changes. The two-state model without …
ligand binding through large-scale conformational changes. The two-state model without …
Spontaneous quaternary and tertiary TR transitions of human hemoglobin in molecular dynamics simulation
We present molecular dynamics simulations of unliganded human hemoglobin (Hb) A under
physiological conditions, starting from the R, R2, and T state. The simulations were carried …
physiological conditions, starting from the R, R2, and T state. The simulations were carried …