Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …

Senescent cells, which accumulate in organisms over time, contribute to age-related tissue
decline. Genetic ablation of senescent cells can ameliorate various age-related pathologies …

Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting
(IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect …

The study of the intestinal or gut microbiome is a newer field that is rapidly gaining attention.
Bidirectional communication between gut microbes and the host can impact numerous …

Obesity and type 2 diabetes are associated with low-grade inflammation and specific
changes in gut microbiota composition 1, 2, 3, 4, 5, 6, 7. We previously demonstrated that …

Obesity is a global epidemic, affecting roughly 30% of the world's population and predicted
to rise. This disease results from genetic, behavioral, societal, and environmental factors …

The human body hosts an enormous abundance and diversity of microbes, which perform a
range of essential and beneficial functions. Our appreciation of the importance of these …

Abstract Type 2 diabetes (T2D) and its target organ injuries cause distressing impacts on
personal health and put an enormous burden on the healthcare system, and increasing …

The high energy demand of the brain renders it sensitive to changes in energy fuel supply
and mitochondrial function. Deficits in glucose availability and mitochondrial function are …