[HTML][HTML] Obesity, male infertility, and the sperm epigenome
Obesity is a growing epidemic and a common problem among reproductive-age men that
can both cause and exacerbate male-factor infertility by means of endocrine abnormalities …
can both cause and exacerbate male-factor infertility by means of endocrine abnormalities …
Mitochondrial reactive oxygen species (ROS) production alters sperm quality
R Chianese, R Pierantoni - Antioxidants, 2021 - mdpi.com
Besides ATP production, mitochondria are key organelles in several cellular functions, such
as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the …
as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the …
Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis
This systematic review investigated the effect of paternal obesity on reproductive potential.
Databases searched were Pubmed, Ovid, Web of Science, Scopus, Cinahl and Embase …
Databases searched were Pubmed, Ovid, Web of Science, Scopus, Cinahl and Embase …
Obesity-related DNA methylation at imprinted genes in human sperm: results from the TIEGER study
A Soubry, L Guo, Z Huang, C Hoyo, S Romanus… - Clinical …, 2016 - Springer
Background Epigenetic reprogramming in mammalian gametes resets methylation marks
that regulate monoallelic expression of imprinted genes. In males, this involves erasure of …
that regulate monoallelic expression of imprinted genes. In males, this involves erasure of …
Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring
Obesity and type 2 diabetes are increasingly prevalent across all demographics. Paternal
obesity in humans and rodents can program obesity and impair insulin sensitivity in female …
obesity in humans and rodents can program obesity and impair insulin sensitivity in female …
Early programming of reproductive health and fertility: novel neuroendocrine mechanisms and implications in reproductive medicine
MA Sánchez-Garrido, D García-Galiano… - Human …, 2022 - academic.oup.com
BACKGROUND According to the Developmental Origins of Health and Disease (DOHaD)
hypothesis, environmental changes taking place during early maturational periods may alter …
hypothesis, environmental changes taking place during early maturational periods may alter …
Peri-conception parental obesity, reproductive health, and transgenerational impacts
Maternal over-nutrition during pregnancy is a risk factor for pregnancy complications and is
increasingly associated with adverse childhood outcomes such as increased propensity for …
increasingly associated with adverse childhood outcomes such as increased propensity for …
Paternal obesity, interventions, and mechanistic pathways to impaired health in offspring
Background: The global rates of male overweight/obesity are rising, approaching 70% of the
total adult population in Western nations. Overweight/obesity increases the risk of chronic …
total adult population in Western nations. Overweight/obesity increases the risk of chronic …
Oxidative stress in mouse sperm impairs embryo development, fetal growth and alters adiposity and glucose regulation in female offspring
Paternal health cues are able to program the health of the next generation however the
mechanism for this transmission is unknown. Reactive oxygen species (ROS) are increased …
mechanism for this transmission is unknown. Reactive oxygen species (ROS) are increased …
High‐fat diets reduce male reproductive success in animal models: A systematic review and meta‐analysis
Sperm counts have shown a progressive decline across the world since the mid‐1900s.
Global rates of obesity have been climbing at a similarly alarming rate, suggesting that these …
Global rates of obesity have been climbing at a similarly alarming rate, suggesting that these …