Observations about the number, frequency, effect size, and genomic distribution of alleles
associated with complex traits must be interpreted in light of evolutionary process. These …

Common and rare alleles are now being annotated across millions of human genomes, and
omics technologies are increasingly being used to develop health and treatment …

Despite the remarkable cognitive power, humans are not alien beings living in their isolated
universe but part of the Earth's biosphere–a dynamic, intelligent system. The working of the …

Compared to its predecessors, the Telomere-to-Telomere CHM13 genome adds nearly 200
million base pairs of sequence, corrects thousands of structural errors, and unlocks the most …

Understanding the genetic changes underlying phenotypic variation in sheep (Ovis aries)
may facilitate our efforts towards further improvement. Here, we report the deep …

Genome sequences are known for two archaic hominins—Neanderthals and Denisovans—
which interbred with anatomically modern humans as they dispersed out of Africa. We …

Adaptive evolution in new or changing environments can be difficult to predict because the
functional connections between genotype, phenotype, and fitness are complex. Here, we …

Modern humans inhabit a variety of environments and are exposed to a plethora of selective
pressures, leading to multiple genetic adaptations to local environmental conditions. These …

Most current methods for detecting natural selection from DNA sequence data are limited in
that they are either based on summary statistics or a composite likelihood, and as a …

Although sled dogs are one of the most specialized groups of dogs, their origin and
evolution has received much less attention than many other dog groups. We applied a …