A long standing problem in structural bioinformatics is to determine the three-dimensional (3-
D) structure of a protein when only a sequence of amino acid residues is given. Many …

Protein remote homology detection is one of the most fundamental and central problems for
the studies of protein structures and functions, aiming to detect the distantly evolutionary …

Inspired by the relatively simple morphological blueprint provided by batoid fish such as
stingrays and skates, we created a biohybrid system that enables an artificial animal—a …

The ongoing Zika virus (ZIKV) outbreak is linked to severe neurological disorders. ZIKV
relies on its NS2B/NS3 protease for polyprotein processing; hence, this enzyme is an …

Resistance to endocrine therapy occurs in virtually all patients with estrogen receptor α
(ERα)-positive metastatic breast cancer, and is attributed to various mechanisms including …

HIV-1 vaccine design is informed by structural studies elucidating mechanisms by which
broadly neutralizing antibodies (bNAbs) recognize and/or accommodate N-glycans on the …

The unprecedented pace of the sequencing of the SARS-CoV-2 virus genomes provides us
with unique information about the genetic changes in a single pathogen during ongoing …

Despite their importance in maintaining the integrity of all cellular pathways, the role of
mutations on protein-protein interaction (PPI) interfaces as cancer drivers has not been …

Lin28 is an essential RNA-binding protein that is ubiquitously expressed in embryonic stem
cells. Its physiological function has been linked to the regulation of differentiation …

Lignins result from the oxidative polymerization of three hydroxycinnamyl (p-coumaryl,
coniferyl, and sinapyl) alcohols in a reaction mediated by peroxidases. The most important …