G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and
an important class of drug targets, play a role in maintaining numerous physiological …

G protein-coupled receptors (GPCRs), the largest family of transmembrane proteins,
regulate a wide array of physiological processes in response to extracellular signals …

The µ-opioid receptor (µOR) is a well-established target for analgesia, yet conventional
opioid receptor agonists cause serious adverse effects, notably addiction and respiratory …

The activation of a G protein–coupled receptor (GPCR) leads to the formation of a ternary
complex between agonist, receptor, and G protein that is characterized by high-affinity …

Abstract The neurotensin receptor 1 (NTS1) is a G protein-coupled receptor (GPCR) with
promise as a drug target for the treatment of pain, schizophrenia, obesity, addiction, and …

G protein–coupled receptors engage both G proteins and β-arrestins, and their coupling can
be biased by ligands and mutations. Here, to resolve structural elements and mechanisms …

A surprisingly clear picture of the allosteric mechanism connecting G protein-coupled
receptor agonists with G protein binding—and back–is revealed by a puzzle of thirty novel …

The M3 muscarinic acetylcholine receptor (M 3 R) is a G protein–coupled receptor (GPCR)
that regulates important physiologic processes, including vascular tone, bronchoconstriction …

G protein-coupled receptors (GPCRs) are the largest human membrane protein family that
transduce extracellular signals into cellular responses. They are major pharmacological …

Class AG protein‐coupled receptors (GPCRs) continue to garner interest for their essential
roles in cell signalling and their importance as drug targets. Although numerous drugs in the …