Microbiome-based therapeutics

MT Sorbara, EG Pamer - Nature Reviews Microbiology, 2022 - nature.com
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …

[HTML][HTML] The spread of antibiotic resistance to humans and potential protection strategies

D Ding, B Wang, X Zhang, J Zhang, H Zhang… - Ecotoxicology and …, 2023 - Elsevier
Antibiotic resistance is currently one of the greatest threats to human health. Widespread
use and residues of antibiotics in humans, animals, and the environment can exert selective …

Microbiome diversity protects against pathogens by nutrient blocking

F Spragge, E Bakkeren, MT Jahn, E BN Araujo… - Science, 2023 - science.org
The human gut microbiome plays an important role in resisting colonization of the host by
pathogens, but we lack the ability to predict which communities will be protective. We …

[HTML][HTML] Mother-to-infant microbiota transmission and infant microbiota development across multiple body sites

D Bogaert, GJ Van Beveren, EM de Koff, PL Parga… - Cell Host & Microbe, 2023 - cell.com
Early-life microbiota seeding and subsequent development is crucial to future health.
Cesarean-section (CS) birth, as opposed to vaginal delivery, affects early mother-to-infant …

[HTML][HTML] Microbiome-based interventions to modulate gut ecology and the immune system

TCA Hitch, LJ Hall, SK Walsh, GE Leventhal, E Slack… - Mucosal …, 2022 - Elsevier
The gut microbiome lies at the intersection between the environment and the host, with the
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …

Commensal consortia decolonize Enterobacteriaceae via ecological control

M Furuichi, T Kawaguchi, MM Pust, K Yasuma-Mitobe… - Nature, 2024 - nature.com
Persistent colonization and outgrowth of potentially pathogenic organisms in the intestine
can result from long-term antibiotic use or inflammatory conditions, and may perpetuate …

Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms

L Osbelt, ÉH Almási, M Wende, S Kienesberger… - Nature …, 2024 - nature.com
The Klebsiella oxytoca species complex is part of the human microbiome, especially during
infancy and childhood. K. oxytoca species complex strains can produce enterotoxins …

Salmonella Typhimurium expansion in the inflamed murine gut is dependent on aspartate derived from ROS-mediated microbiota lysis

W Yoo, NG Shealy, JK Zieba, TP Torres, M Baltagulov… - Cell host & …, 2024 - cell.com
Inflammation boosts the availability of electron acceptors in the intestinal lumen, creating a
favorable niche for pathogenic Enterobacteriaceae. However, the mechanisms linking …

Intestinal colonization resistance in the context of environmental, host, and microbial determinants

S Woelfel, MS Silva, B Stecher - Cell host & microbe, 2024 - cell.com
Microbial communities that colonize the human gastrointestinal (GI) tract defend against
pathogens through a mechanism known as colonization resistance (CR). Advances in …

Intrahost evolution of the gut microbiota

HC Barreto, I Gordo - Nature Reviews Microbiology, 2023 - nature.com
A massive number of microorganisms, belonging to different species, continuously divide
inside the guts of animals and humans. The large size of these communities and their rapid …