Understanding key mechanisms of exercise-induced cardiac protection to mitigate disease: current knowledge and emerging concepts

BC Bernardo, JYY Ooi, KL Weeks… - Physiological …, 2018 - journals.physiology.org
The benefits of exercise on the heart are well recognized, and clinical studies have
demonstrated that exercise is an intervention that can improve cardiac function in heart …

The role of long non-coding RNA GAS5 in cancers

J Ji, X Dai, SCJ Yeung, X He - Cancer management and research, 2019 - Taylor & Francis
Long non-coding RNAs (lncRNAs) have shown potential as a biomarker in the diagnosis
and prognosis in multiple cancers. LncRNAs are dysregulated in various cancers, playing …

'Multimorbidity'as the manifestation of network disturbances

JP Sturmberg, JM Bennett, CM Martin… - Journal of evaluation …, 2017 - Wiley Online Library
We argue that 'multimorbidity'is the manifestation of interconnected physiological network
processes within an individual in his or her socio‐cultural environment. Networks include …

Health and disease—emergent states resulting from adaptive social and biological network interactions

JP Sturmberg, M Picard, DC Aron, JM Bennett… - Frontiers in …, 2019 - frontiersin.org
Health is an adaptive state unique to each person. This subjective state must be
distinguished from the objective state of disease. The experience of health and illness (or …

β-Arrestin based receptor signaling paradigms: Potential therapeutic targets for complex age-related disorders

J Van Gastel, JO Hendrickx, H Leysen… - Frontiers in …, 2018 - frontiersin.org
G protein coupled receptors (GPCRs) were first characterized as signal transducers that
elicit downstream effects through modulation of guanine (G) nucleotide-binding proteins …

The fractal heart—embracing mathematics in the cardiology clinic

G Captur, AL Karperien, AD Hughes… - Nature Reviews …, 2017 - nature.com
For clinicians grappling with quantifying the complex spatial and temporal patterns of
cardiac structure and function (such as myocardial trabeculae, coronary microvascular …

Biopsychosocial approach to understanding resilience: Stress habituation and where to intervene

JM Bennett, N Rohleder… - Journal of Evaluation in …, 2018 - Wiley Online Library
Background Resilience in the face of adversity is a human experience that leads to better
health, both mentally and physically. We briefly review its historical origins rooted in …

Comprehensive viewpoints on heart rate variability at high altitude

J Hou, K Lu, P Chen, P Wang, J Li, J Yang… - Clinical and …, 2023 - Taylor & Francis
Objectives Hypoxia is a physiological state characterized by reduced oxygen levels in
organs and tissues. It is a common clinicopathological process and a major cause of health …

24-h continuous non-invasive multiparameter home monitoring of vitals in patients with Rett syndrome by an innovative wearable technology: evidence of an …

S Leoncini, L Boasiako, S Di Lucia, A Beker… - Frontiers in …, 2024 - frontiersin.org
Background Sleep is disturbed in Rett syndrome (RTT), a rare and progressive
neurodevelopmental disorder primarily affecting female patients (prevalence 7.1/100,000 …

Evidence‐based medicine—Not a panacea for the problems of a complex adaptive world

JP Sturmberg - Journal of evaluation in clinical practice, 2019 - Wiley Online Library
The recent sacking of Peter Gøtzsche from the Cochrane Collaboration Board raised strong
responses and highlights the neglected issue about priorities—maintaining the reputation of …