[HTML][HTML] GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease

J Jiménez-Balado, TS Eich - Seminars in cell & developmental biology, 2021 - Elsevier
In this review, we focus on the potential role of the γ-aminobutyric acidergic (GABAergic)
system in age-related episodic memory impairments in humans, with a particular focus on …

A Guide to the Metabolic Pathways and Function of Metabolites Observed in Human Brain 1H Magnetic Resonance Spectra

CD Rae - Neurochemical research, 2014 - Springer
The current knowledge of the normal biochemistry of compounds that give rise to
resonances in human brain proton magnetic resonance spectra measureable at readily …

Impact of aging on the auditory system and related cognitive functions: a narrative review

DMP Jayakody, PL Friedland, RN Martins… - Frontiers in …, 2018 - frontiersin.org
Age-related hearing loss (ARHL), presbycusis, is a chronic health condition that affects
approximately one-third of the world's population. The peripheral and central hearing …

Not all brains are created equal: the relevance of individual differences in responsiveness to transcranial electrical stimulation

B Krause, R Cohen Kadosh - Frontiers in systems neuroscience, 2014 - frontiersin.org
A current issue in the research of augmentation of brain functions using transcranial
electrical stimulation (tES) is the diversity and inconsistency in outcome results. Similar …

Alzheimer's disease: targeting the glutamatergic system

ME Conway - Biogerontology, 2020 - Springer
Alzheimer's disease (AD) is a debilitating neurodegenerative disease that causes a
progressive decline in memory, language and problem solving. For decades mechanism …

Functional MRS studies of GABA and glutamate/Glx–A systematic review and meta-analysis

D Pasanta, JL He, T Ford, G Oeltzschner… - Neuroscience & …, 2023 - Elsevier
Functional magnetic resonance spectroscopy (fMRS) can be used to investigate
neurometabolic responses to external stimuli in-vivo, but findings are inconsistent. We …

Frontal gamma-aminobutyric acid concentrations are associated with cognitive performance in older adults

EC Porges, AJ Woods, RAE Edden, NAJ Puts… - Biological psychiatry …, 2017 - Elsevier
Background Gamma-aminobutyric acid (GABA), the brain's principal inhibitory
neurotransmitter, has been associated with perceptual and attentional functioning. Recent …

Edited 1H magnetic resonance spectroscopy in vivo: Methods and metabolites

AD Harris, MG Saleh… - Magnetic resonance in …, 2017 - Wiley Online Library
The Proton magnetic resonance (1H‐MRS) spectrum contains information about the
concentration of tissue metabolites within a predefined region of interest (a voxel). The …

Anxious individuals shift emotion control from lateral frontal pole to dorsolateral prefrontal cortex

B Bramson, S Meijer, A van Nuland, I Toni… - Nature …, 2023 - nature.com
Anxious individuals consistently fail in controlling emotional behavior, leading to excessive
avoidance, a trait that prevents learning through exposure. Although the origin of this failure …

Sensorimotor network segregation declines with age and is linked to GABA and to sensorimotor performance

K Cassady, H Gagnon, P Lalwani, M Simmonite… - Neuroimage, 2019 - Elsevier
Aging is typically associated with declines in sensorimotor performance. Previous studies
have linked some age-related behavioral declines to reductions in network segregation. For …