Structural stabilization of clinically oriented oligomeric proteins during their transit through synthetic secretory amyloids

JM Sánchez, H López‐Laguna, E Parladé… - Advanced …, 2024 - Wiley Online Library
Develo** time‐sustained drug delivery systems is a main goal in innovative medicines.
Inspired by the architecture of secretory granules from the mammalian endocrine system it …

[HTML][HTML] Lyophilization of biomimetic amyloids preserves their regulatable, endocrine-like functions for nanoparticle release

MTP Favaro, H López-Laguna, E Voltà-Durán… - Applied Materials …, 2024 - Elsevier
The secretory granules from the mammalian endocrine system are functional amyloids that
act as dynamic depots to store and release protein hormones into the bloodstream. The …

Hybrid micro-/nanoprotein platform provides endocrine-like and extracellular matrix-like cell delivery of growth factors

H López-Laguna, PM Tsimbouri… - … applied materials & …, 2024 - ACS Publications
Protein materials are versatile tools in diverse biomedical fields. Among them, artificial
secretory granules (SGs), mimicking those from the endocrine system, act as mechanically …

Citrate-Assisted Regulation of Protein Stability and Secretability from Synthetic Amyloids

H López-Laguna, MTP Favaro… - … Applied Materials & …, 2025 - ACS Publications
The mammalian endocrine system uses functional amyloids as dynamic depots to store and
release protein hormones into the bloodstream. Such depots, acting as secretory granules …

Surpassing protein specificity in biomimetics of bacterial amyloids

JM Sanchez, E Voltà-Durán, E Parladé… - International Journal of …, 2025 - Elsevier
In nature, nontoxic protein amyloids serve as dynamic, protein-specific depots, exemplified
by both bacterial inclusion bodies and secretory granules from the endocrine system …

[HTML][HTML] Investigating the role of phenylalanine residues for amyloid formation of the neuropeptide neurokinin B

BM Jayawardena, A Azzi, CE Jones - Biochemical and Biophysical …, 2024 - Elsevier
Neurokinin B (NKB) is a tachykinin peptide that has diverse roles in biology, including in
human reproductive development. Cellular processing of this peptide is thought to involve …

Zinc-Assisted Microscale Granules Made of the SARS-CoV-2 Spike Protein Trigger Neutralizing, Antivirus Antibody Responses

MTP Favaro, P Alamo, N Roher, M Chillon… - ACS Materials …, 2024 - ACS Publications
The development of new and more efficient vaccination approaches is a constant need, due
to the pressure of historical and emerging infectious diseases and the limited efficacy and …