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Structural stabilization of clinically oriented oligomeric proteins during their transit through synthetic secretory amyloids
Develo** time‐sustained drug delivery systems is a main goal in innovative medicines.
Inspired by the architecture of secretory granules from the mammalian endocrine system it …
Inspired by the architecture of secretory granules from the mammalian endocrine system it …
[HTML][HTML] Lyophilization of biomimetic amyloids preserves their regulatable, endocrine-like functions for nanoparticle release
The secretory granules from the mammalian endocrine system are functional amyloids that
act as dynamic depots to store and release protein hormones into the bloodstream. The …
act as dynamic depots to store and release protein hormones into the bloodstream. The …
Hybrid micro-/nanoprotein platform provides endocrine-like and extracellular matrix-like cell delivery of growth factors
Protein materials are versatile tools in diverse biomedical fields. Among them, artificial
secretory granules (SGs), mimicking those from the endocrine system, act as mechanically …
secretory granules (SGs), mimicking those from the endocrine system, act as mechanically …
Citrate-Assisted Regulation of Protein Stability and Secretability from Synthetic Amyloids
The mammalian endocrine system uses functional amyloids as dynamic depots to store and
release protein hormones into the bloodstream. Such depots, acting as secretory granules …
release protein hormones into the bloodstream. Such depots, acting as secretory granules …
Surpassing protein specificity in biomimetics of bacterial amyloids
In nature, nontoxic protein amyloids serve as dynamic, protein-specific depots, exemplified
by both bacterial inclusion bodies and secretory granules from the endocrine system …
by both bacterial inclusion bodies and secretory granules from the endocrine system …
[HTML][HTML] Investigating the role of phenylalanine residues for amyloid formation of the neuropeptide neurokinin B
Neurokinin B (NKB) is a tachykinin peptide that has diverse roles in biology, including in
human reproductive development. Cellular processing of this peptide is thought to involve …
human reproductive development. Cellular processing of this peptide is thought to involve …
Nanoparticle-Based Secretory Granules Induce a Specific and Long-Lasting Immune Response through Prolonged Antigen Release
Develo** prolonged antigen delivery systems that mimic long-term exposure to pathogens
appears as a promising but still poorly explored approach to reach durable immunities. In …
appears as a promising but still poorly explored approach to reach durable immunities. In …
Zinc-Assisted Microscale Granules Made of the SARS-CoV-2 Spike Protein Trigger Neutralizing, Antivirus Antibody Responses
The development of new and more efficient vaccination approaches is a constant need, due
to the pressure of historical and emerging infectious diseases and the limited efficacy and …
to the pressure of historical and emerging infectious diseases and the limited efficacy and …