Friedreich ataxia (FRDA) is a rare autosomal recessive hereditary disorder that affects
approximately 1 in 50,000 Caucasians. It is caused by hyperexpansion of GAA repeats in …

This is an exciting time in the study of Friedreich's ataxia. Over the last 10 years much
progress has been made in uncovering the mechanisms, whereby the Frataxin gene is …

Gross chromosomal rearrangements (including translocations, deletions, insertions and
duplications) are a hallmark of cancer genomes and often create oncogenic fusion genes …

Expansion of the GAA/TTC repeats in the first intron of the FXN gene causes Friedreich's
ataxia. Non-canonical structures are linked to this expansion. DNA triplexes and R-loops are …

More than 15 human genetic diseases have been associated with the expansion of
trinucleotide DNA repeats, which may involve the formation of non‐duplex DNA structures …

p53 plays critical roles in regulating cell cycle, apoptosis, senescence and metabolism and
is commonly mutated in human cancer. These roles are achieved by interaction with other …

Acinetobacter baumannii, an important nosocomial pathogen, is increasingly becoming
resistant to antibiotics including recent β-lactam like imipenem. Production of different types …

It is now established that a small fraction of genomic DNA does adopt the non-canonical B-
DNA structure or 'unusual'DNA structure. The unusual DNA structures like DNA-hairpin …

Expansion of simple triplet repeats (TNR) underlies more than 30 severe degenerative
diseases. There is a good understanding of the major pathways generating an expansion …

Expansion of (GAA) n repeats in the first intron of the Frataxin gene is associated with
reduced mRNA and protein levels and the development of Friedreich's ataxia.(GAA) n …