Engineered exosomes derived from miR-132-overexpresssing adipose stem cells promoted diabetic wound healing and skin reconstruction

L Ge, K Wang, H Lin, E Tao, W **a, F Wang… - … in bioengineering and …, 2023 - frontiersin.org
The tissue reconstruction of diabetic wounds mainly depends on the proliferation and
remodelling of cutaneous cells around wounds and the transplantation of random skin flaps …

Multifunctional roles of the actin-binding protein flightless I in inflammation, cancer and wound healing

XL Strudwick, AJ Cowin - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
Flightless I is an actin-binding member of the gelsolin family of actin-remodeling proteins
that inhibits actin polymerization but does not possess actin severing ability. Flightless I …

Pro-and anti-angiogenic factors: their relevance in diabetic foot syndrome—a review

M Schönborn, P Łączak, P Pasieka, S Borys… - …, 2022 - journals.sagepub.com
Peripheral arterial disease can involve tissue loss in up to 50% of patients with diabetic foot
syndrome (DFS). Consequently, revascularization of narrowed or occluded arteries is one of …

Reforming the barrier: The role of Formins in wound repair

P Ahangar, AJ Cowin - Cells, 2022 - mdpi.com
The restoration of an intact epidermal barrier after wound injury is the culmination of a highly
complex and exquisitely regulated physiological process involving multiple cells and …

Flightless I negatively regulates macrophage surface TLR4, delays early inflammation, and impedes wound healing

SJ Mills, P Ahangar, HM Thomas, BR Hofma… - Cells, 2022 - mdpi.com
TLR4 plays a pivotal role in orchestrating inflammation and tissue repair. Its expression has
finally been balanced to initiate the early, robust immune response necessary for efficient …

Wound healing from an actin cytoskeletal perspective

P Ahangar, XL Strudwick… - Cold Spring Harbor …, 2022 - cshperspectives.cshlp.org
Wound healing requires a complex cascade of highly controlled and conserved cellular and
molecular processes. These involve numerous cell types and extracellular matrix molecules …

Analyzing secretory proteins in human dermal fibroblast‐conditioned medium for angiogenesis: A bioinformatic approach

SB Suh, JY Suh, SB Cho - Skin Research and Technology, 2024 - Wiley Online Library
Background The conditioned medium from human dermal fibroblasts (dermal fibroblast‐
conditioned medium; DFCM) contains a diverse array of secretory proteins, including growth …

Role of pericytes in diabetic angiogenesis

T Wang, G Zang, L Zhang, Z Sun, J Liu… - Journal of …, 2022 - journals.lww.com
In the context of diabetes mellitus, various pathological changes cause tissue ischemia and
hypoxia, which can lead to the compensatory formation of neovascularization. However …

Plasma-polymerized pericyte patches improve healing of murine wounds through increased angiogenesis and reduced inflammation

HM Thomas, P Ahangar, R Fitridge… - Regenerative …, 2021 - academic.oup.com
Pericytes have the potential to be developed as a cell therapy for the treatment of wounds;
however, the efficacy of any cell therapy relies on the successful delivery of intact and …

Physiology and proteomic basis of lung adaptation to high-altitude hypoxia in Tibetan sheep

P Zhao, S Li, Z He, F Zhao, J Wang, X Liu, M Li, J Hu… - Animals, 2022 - mdpi.com
Simple Summary As an indigenous animal living in the Tibetan plateau, the Tibetan sheep is
well adapted to high-altitude hypoxia, and the lungs play an important role in overcoming …