Environment-related parameters, including viscosity, polarity, temperature, hypoxia, and pH,
play pivotal roles in controlling the physical or chemical behaviors of local molecules. In …

Small-molecule fluorescent probes embody an essential facet of chemical biology. Although
numerous compounds are known, the ensemble of fluorescent probes is based on a modest …

The adenosine class of heterotrimeric guanine nucleotide–binding protein (G protein)–
coupled receptors (GPCRs) mediates the important role of extracellular adenosine in many …

Solvatochromism is commonly used in many fields of chemical and biological research to
study bulk and local polarity in macrosystems (membranes, etc.), or even the conformation …

Solvatochromic fluorophores possess emission properties that are sensitive to the nature of
the local microenvironment. These dyes have been exploited in applications ranging from …

Due to their unique three-dimensional framework and intriguing electronic properties,[2.2]
paracyclophanes (pCps) have been employed over the years as building blocks in materials …

Proper three-dimensional structures are essential for maintaining the functionality of proteins
and for avoiding pathological consequences of improper folding. Misfolding and …

In a search for environmentally sensitive (solvatochromic) dyes with superior properties, we
extended the electronic conjugation of one of the best solvatochromic dyes, Prodan, by …

Polarity-dependent fluorescent probes are recently attracting interest for high-resolution cell
imaging. Following a stepwise rational approach, we prepared and tested a toolbox of new …

Human serum albumin (HSA) is the core protein in the systemic circulation and has a
fundamental role in transportation and distribution of ligands in-vivo. In this study, a newly …