Many cell signaling pathways are orchestrated by the weak, transient, and reversible protein–
protein interactions that are mediated by the binding of a short peptide segment in one …

Human angiotensin‐converting enzyme (ACE) is a well‐established druggable target for the
treatment of hypertension (HTN), which contains two structurally homologous but …

Drug-induced adverse reactions are a significant problem in healthcare worldwide and are
estimated to cost billions of dollars annually in the United States. A portion of such reactions …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an etiological agent of
the current rapidly growing outbreak of coronavirus disease (COVID-19), which is straining …

Self-binding peptides (SBPs) represent a novel biomolecular phenomenon spanning
between folding and binding, where a short peptide segment within a monomeric protein …

Self-binding peptide (SBP) represents a novel biomolecular phenomenon spanning
between folding and binding. It is a structurally independent, short peptide segment within a …

Abstract Src homology 3 (SH3) domains are small protein modules involved in the
regulation of important cellular pathways such as proliferation and migration, which …

Idiosyncratic drug reactions (IDRs) pose severe threats to patient health. Unlike
conventionally dose-dependent side effects, they are unpredictable and frequently manifest …

Background Human leukocyte antigen (HLA) surface proteins are directly involved in
idiosyncratic adverse drug reactions. Herein, we present a structure-based analysis of the …

Idiosyncratic drug toxicities (IDTs) caused by certain drugs are a significant cause of
morbidity and mortality for patients. As IDTs are not normally detected even during clinical …