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[HTML][HTML] Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications
Q Kang, C Yang - Redox biology, 2020 - Elsevier
Oxidative stress, a cytopathic outcome of excessive generation of ROS and the repression of
antioxidant defense system for ROS elimination, is involved in the pathogenesis of multiple …
antioxidant defense system for ROS elimination, is involved in the pathogenesis of multiple …
Molecular mechanism of VEGF and its role in pathological angiogenesis
Over the last seven decades, a significant scientific contribution took place in the delineation
of the implications of vascular endothelial‐derived growth factor (VEGF) in the processes of …
of the implications of vascular endothelial‐derived growth factor (VEGF) in the processes of …
Oxidative stress, inflammatory, angiogenic, and apoptotic molecules in proliferative diabetic retinopathy and diabetic macular edema patients
I Andrés-Blasco, A Gallego-Martínez… - International journal of …, 2023 - mdpi.com
The aim of this study is to evaluate molecules involved in oxidative stress (OS),
inflammation, angiogenesis, and apoptosis, and discern which of these are more likely to be …
inflammation, angiogenesis, and apoptosis, and discern which of these are more likely to be …
Single-cell transcriptomics reveals novel role of microglia in fibrovascular membrane of proliferative diabetic retinopathy
Z Hu, X Mao, M Chen, X Wu, T Zhu, Y Liu, Z Zhang… - Diabetes, 2022 - diabetesjournals.org
Vitreous fibrovascular membranes (FVMs), the hallmark of proliferative diabetic retinopathy
(PDR), cause retinal hemorrhage, detachment, and eventually blindness. However, little is …
(PDR), cause retinal hemorrhage, detachment, and eventually blindness. However, little is …
A self-healing and injectable hydrogel based on water-soluble chitosan and hyaluronic acid for vitreous substitute
S Wang, J Chi, Z Jiang, H Hu, C Yang, W Liu… - Carbohydrate …, 2021 - Elsevier
Vitreous, an essential dioptric medium for the human eyes, must be filled with artificial
materials once damaged. Carboxymethyl chitosan (CMCTS) is one of the most important …
materials once damaged. Carboxymethyl chitosan (CMCTS) is one of the most important …
Studies of the retinal microcirculation using human donor eyes and high-resolution clinical imaging: insights gained to guide future research in diabetic retinopathy
The microcirculation plays a key role in delivering oxygen to and removing metabolic wastes
from energy-intensive retinal neurons. Microvascular changes are a hallmark feature of …
from energy-intensive retinal neurons. Microvascular changes are a hallmark feature of …
[HTML][HTML] Aging and diabetic retinopathy: Inherently intertwined pathophysiological processes
Q Li, M Wang, X Li, Y Shao - Experimental Gerontology, 2023 - Elsevier
Diabetic retinopathy (DR) is a leading cause of blindness worldwide and a costly
complication of diabetes mellitus (DM). DR severity is associated with DM duration; thus, DR …
complication of diabetes mellitus (DM). DR severity is associated with DM duration; thus, DR …
Proteomics profiling of vitreous humor reveals complement and coagulation components, adhesion factors, and neurodegeneration markers as discriminatory …
Introduction Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are
leading causes of visual impairment and blindness in people aged 50 years or older in …
leading causes of visual impairment and blindness in people aged 50 years or older in …
Angiogenesis-inflammation cross talk in diabetic retinopathy: novel insights from the chick embryo chorioallantoic membrane/human vitreous platform
Pathological angiogenesis of the retina is a key component of irreversible causes of
blindness, as observed in proliferative diabetic retinopathy (PDR). The pathogenesis of PDR …
blindness, as observed in proliferative diabetic retinopathy (PDR). The pathogenesis of PDR …
Vitreous humor proteome: unraveling the molecular mechanisms underlying proliferative and neovascular vitreoretinal diseases
Proliferative diabetic retinopathy (PDR), proliferative vitreoretinopathy (PVR), and
neovascular age-related macular degeneration (nAMD) are among the leading causes of …
neovascular age-related macular degeneration (nAMD) are among the leading causes of …