Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on
health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast …

RNA editing, which adds sequence information to RNAs post‐transcriptionally, is a
widespread phenomenon throughout eukaryotes. The most complex form of this process is …

Uridine insertion/deletion RNA editing in kinetoplastids entails the addition and deletion of
uridine residues throughout the length of mitochondrial transcripts to generate translatable …

Uridine insertion/deletion RNA editing is an essential process in kinetoplastid parasites
whereby mitochondrial mRNAs are modified through the specific insertion and deletion of …

Kinetoplastid protists such as Trypanosoma brucei undergo an unusual process of
mitochondrial uridine (U) insertion and deletion editing termed kinetoplastid RNA editing …

RNA editing causes massive remodeling of the mitochondrial mRNA transcriptome in
trypanosomes and related kinetoplastid protozoa. This type of editing involves the specific …

Most mitochondrial mRNAs in kinetoplastids require extensive uridine insertion/deletion
editing to generate translatable open reading frames. Editing is specified by trans-acting …

Uridine insertion/deletion editing of mitochondrial mRNAs is a characteristic feature of
kinetoplastids, including Trypanosoma brucei. Editing is directed by trans-acting gRNAs and …

The trypanosome R NA e diting s ubstrate binding c omplex (RESC) acts as the platform for
mitochondrial uridine insertion/deletion RNA editing and facilitates the protein–protein and …