Environmental exposure to a mixture of chemical xenobiotics acts as a double-edged sword,
promoting or suppressing tumorigenesis and the development of breast cancer (BC). Before …

Aims Curcumin is a natural compound and has good antitumor properties, but its clinical use
is limited by its low bioavailability. We constructed the derivative CP41 (3, 5-bis (2 …

There are three distinct forms of autophagy, namely, macroautophagy, microautophagy, and
HSPA8 chaperone-mediated autophagy (CMA). While macroautophagy is widely …

The inhibitor of apoptosis protein survivin has a critical regulatory role in carcinogenesis and
treatment tolerance in colorectal cancer (CRC). However, the targeted drugs for survivin …

Abstract Yin Yang 1 (YY1) is a key transcription factor that has been implicated in the
development of several malignancies. The stability of YY1 is regulated by the ubiquitin …

This review aims to outline mitotic kinase inhibitors' roles as potential therapeutic targets and
assess their suitability as a stand-alone clinical therapy or in combination with standard …

Various studies have shown that the cell-cycle-related regulatory proteins UBE2C, PLK1,
and BIRC5 promote cell proliferation and migration in different types of cancer. However …

African American (AA) women are twice as likely to develop triple-negative breast cancer
(TNBC) as women of European descent. Additionally, AA women with TNBC present a much …

The activation of hypoxia-inducible factors (HIF)-1α and 2α in the liver is closely linked to the
progression of fatty liver diseases. Prior studies indicated that disrupting hepatocyte HIF-2α …

Abstract Polo-like kinase 1 (PLK1) is an essential mitotic checkpoint protein that plays a key
role in cell cycle division. Overexpression of PLK1 has been associated with poor prognosis …