In C. elegans, mutants that are defective in muscle function and/or structure are easy to
detect and analyze since: 1) body wall muscle is essential for locomotion, and 2) muscle …

Sarcomeres within body wall muscle in C. elegans include attachments to the sarcolemma
that are remarkably similar in structure to vertebrate adhesion complexes. Crucial early …

Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a severe global health crisis; …

Autophagy is the mechanism by which cytoplasmic components and organelles are
degraded by the lysosomal machinery in response to diverse stimuli including nutrient …

Highly regulated cell migration events are crucial during animal tissue formation and the
trafficking of cells to sites of infection and injury. Misregulation of cell movement underlies …

A crucial step in the development of muscle cells in all metazoan animals is the assembly
and anchorage of the sarcomere, the essential repeat unit responsible for muscle …

Ubiquitin is a highly conserved 76 amino acid polypeptide, which is covalently attached to
target proteins to signal their degradation by the 26S proteasome or to modify their function …

In several types of animals, muscle cells use membrane extensions to contact motor axons
during development. To better understand the process of membrane extension in muscle …

Duchenne muscular dystrophy (DMD) is a genetic disease characterized by progressive
muscle degeneration due to mutations in the dystrophin gene. In spite of great advances in …

Background Caenorhabditis elegans has been widely used as a model to study muscle
structure and function. Its body wall muscle is functionally and structurally similar to …