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The cGAS–STING pathway and cancer
N Samson, A Ablasser - Nature cancer, 2022 - nature.com
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
Bioorthogonal guided activation of cGAS‐STING by AIE photosensitizer nanoparticles for targeted tumor therapy and imaging
M Cui, D Tang, B Wang, H Zhang, G Liang… - Advanced …, 2023 - Wiley Online Library
Photodynamic therapy (PDT) and photothermal therapy (PTT) leverage reactive oxygen
species (ROS) and control local hyperthermia by photosensitizer to perturb intracellular …
species (ROS) and control local hyperthermia by photosensitizer to perturb intracellular …
Inflammatory microenvironment remodelling by tumour cells after radiotherapy
M McLaughlin, EC Patin, M Pedersen, A Wilkins… - Nature Reviews …, 2020 - nature.com
The development of immune checkpoint inhibitors (ICIs) is revolutionizing the way we think
about cancer treatment. Even so, for most types of cancer, only a minority of patients …
about cancer treatment. Even so, for most types of cancer, only a minority of patients …
The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion
As a strategy to improve the therapeutic success of chimeric antigen receptor T cells (CART)
directed against solid tumors, we here test the combinatorial use of CART and IMSA101, a …
directed against solid tumors, we here test the combinatorial use of CART and IMSA101, a …
Dendritic cells and their role in immunotherapy
Despite significant advances in the field of cancer immunotherapy, the majority of patients
still do not benefit from treatment and must rely on traditional therapies. Dendritic cells have …
still do not benefit from treatment and must rely on traditional therapies. Dendritic cells have …
Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …
[HTML][HTML] Dendritic cell paucity leads to dysfunctional immune surveillance in pancreatic cancer
Here, we utilized spontaneous models of pancreatic and lung cancer to examine how
neoantigenicity shapes tumor immunity and progression. As expected, neoantigen …
neoantigenicity shapes tumor immunity and progression. As expected, neoantigen …
The multifaceted role of chromosomal instability in cancer and its microenvironment
Chromosomal instability (CIN) is a hallmark of human cancer, and it is associated with poor
prognosis, metastasis, and therapeutic resistance. CIN results from errors in chromosome …
prognosis, metastasis, and therapeutic resistance. CIN results from errors in chromosome …
Targeting neoantigens to augment antitumour immunity
The past decade of cancer research has been marked by a growing appreciation of the role
of immunity in cancer. Mutations in the tumour genome can cause tumours to express …
of immunity in cancer. Mutations in the tumour genome can cause tumours to express …