Cells of the vascular wall are exquisitely sensitive to changes in their mechanical
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …

Inflammation is a physiological response to aggression of pathogenic agents aimed at
eliminating the aggressor agent and promoting healing. Excessive inflammation, however …

The etiology of aortic aneurysms is poorly understood, but it is associated with
atherosclerosis, hypercholesterolemia, and abnormal transforming growth factor β (TGF-β) …

Hypertension is both a cause and a consequence of central artery stiffening, which in turn is
an initiator and indicator of myriad disease conditions and thus all-cause mortality. Such …

Vascular ageing, characterized by structural and functional changes in blood vessels of
which arterial stiffness and endothelial dysfunction are key components, is associated with …

Background: Myocardial infarction (MI) induces an intense injury response that ultimately
generates a collagen-dominated scar. Although required to prevent ventricular rupture, the …

Aortic dissection continues to be responsible for significant morbidity and mortality, although
recent advances in medical data assimilation and in experimental and in silico models have …

The endothelial to mesenchymal transition (EndMT) is the process by which endothelial
cells lose a portion of their cellular features and obtain certain characteristics of …

Hypertension induces significant aortic remodelling, often adaptive but sometimes not. To
identify immuno-mechanical mechanisms responsible for differential remodelling, we …

Tissue-level biomechanical properties and function derive from underlying cell signaling,
which regulates mass deposition, organization, and removal. Here, we couple two existing …