BACKGROUND Each organ in the human body has its own capillary bed to carry out its
distinctive and versatile functions in response to dynamically changing systemic and local …

The function of the mammalian heart depends on the interplay between different cardiac cell
types. The deployment of these cells, with precise spatiotemporal regulation, is also …

In the mammalian lung, an apparently homogenous mesh of capillary vessels surrounds
each alveolus, forming the vast respiratory surface across which oxygen transfers to the …

Monitoring of cell-cell communication in multicellular organisms is fundamental to
understanding diverse biological processes such as embryogenesis and tumorigenesis. To …

After severe heart injury, fibroblasts are activated and proliferate excessively to form
scarring, leading to decreased cardiac function and eventually heart failure. It is unknown …

Characterizing the stem cells responsible for lung repair and regeneration is important for
the treatment of pulmonary diseases. Recently, a unique cell population located at the …

Current therapies for heart failure after myocardial infarction are limited and non-curative.
Although regenerative approaches are receiving significant attention, clinical efforts that …

Cardiogenesis is a complex developmental process involving multiple overlap** stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …

The Cre–loxP recombination system is the most widely used technology for in vivo tracing of
stem or progenitor cell lineages. The precision of this genetic system largely depends on the …

The field of vascular biology has gained enormous insight from the use of Cre and inducible
Cre mouse models to temporally and spatially manipulate gene expression within the …