Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

The major innate immune cell types involved in tuberculosis (TB) infection are
macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune …

As an ancient infectious disease, tuberculosis (TB) is still the leading cause of death from a
single infectious agent worldwide. Latent TB infection (LTBI) has been recognized as the …

The X chromosome and X-linked variants have largely been ignored in genome-wide and
candidate association studies of infectious diseases due to the complexity of statistical …

Macrophages and neutrophils play a decisive role in host responses to intracellular bacteria
including the agent of tuberculosis (TB), M ycobacterium tuberculosis as they represent the …

Neutrophils have long been considered simple suicide killers at the bottom of the hierarchy
of the immune response. That view began to change 10–20 yr ago, when the sophisticated …

Despite widespread use of the bacille Calmette–Guérin (BCG) vaccine, tuberculosis (TB)
remains a leading cause of global mortality from a single infectious agent (Mycobacterium …

Tuberculosis (TB) lesions are extremely complex and dynamic. Here, we review the multiple
types and fates of pulmonary lesions that form following infection by M ycobacterium …

Immune responses to pathogens are complex and not well understood in many diseases,
and this is especially true for infections by persistent pathogens. One mechanism that allows …

Globally, far more men than women have tuberculosis. Although the cause of this bias is
uncertain, epidemiological factors have historically been considered the driving force. Here …