Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …

The pivotal role of lysosomes in cellular processes is increasingly appreciated. An
understanding of the balanced interplay between the activity of acidic hydrolases, lysosomal …

While serum-circulating complement destroys invading pathogens, intracellularly active
complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic …

Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque.
However, plaque progression renders macrophages unable to degrade exogenous …

Renewed interest in immune cell metabolism has led to the emergence of a research field
aimed at studying the importance of metabolic processes for an effective immune response …

Macrophages are essential innate immune cells and form our first line of immune defense.
Also known as professional phagocytes, macrophages interact and take up various …

Accumulation of lipotoxic lipids, such as free cholesterol, induces hepatocyte death and
subsequent inflammation and fibrosis in the pathogenesis of nonalcoholic steatohepatitis …

Acetaldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme detoxifying
acetaldehyde and endogenous lipid aldehydes; previous studies suggest a protective role of …

Objectives: During the advancement of atherosclerosis, plaque cellularity is governed by the
influx of monocyte-derived macrophages and their turnover via apoptotic and nonapoptotic …

Atherosclerosis is a progressive insidious chronic disease that underlies most of the
cardiovascular pathologies, including myocardial infarction and ischemic stroke. The …