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β Cell dysfunction during progression of metabolic syndrome to type 2 diabetes
In a society where physical activity is limited and food supply is abundant, metabolic
diseases are becoming a serious epidemic. Metabolic syndrome (MetS) represents a cluster …
diseases are becoming a serious epidemic. Metabolic syndrome (MetS) represents a cluster …
Mitochondrial dynamics, mitophagy and cardiovascular disease
Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or
myocardial injury, and allows the heart to meet an increased demand for oxygen. Although …
myocardial injury, and allows the heart to meet an increased demand for oxygen. Although …
Gene co-expression analysis for functional classification and gene–disease predictions
Gene co-expression networks can be used to associate genes of unknown function with
biological processes, to prioritize candidate disease genes or to discern transcriptional …
biological processes, to prioritize candidate disease genes or to discern transcriptional …
WGCNA: an R package for weighted correlation network analysis
Background Correlation networks are increasingly being used in bioinformatics applications.
For example, weighted gene co-expression network analysis is a systems biology method …
For example, weighted gene co-expression network analysis is a systems biology method …
Is my network module preserved and reproducible?
In many applications, one is interested in determining which of the properties of a network
module change across conditions. For example, to validate the existence of a module, it is …
module change across conditions. For example, to validate the existence of a module, it is …
SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress
Mitochondrial morphology is regulated by the balance between two counteracting
mitochondrial processes of fusion and fission. There is significant evidence suggesting a …
mitochondrial processes of fusion and fission. There is significant evidence suggesting a …
The genetics of quantitative traits: challenges and prospects
A major challenge in current biology is to understand the genetic basis of variation for
quantitative traits. We review the principles of quantitative trait locus map** and …
quantitative traits. We review the principles of quantitative trait locus map** and …
Hypoxia-inducible factor 1α induces fibrosis and insulin resistance in white adipose tissue
Adipose tissue can undergo rapid expansion during times of excess caloric intake. Like a
rapidly expanding tumor mass, obese adipose tissue becomes hypoxic due to the inability of …
rapidly expanding tumor mass, obese adipose tissue becomes hypoxic due to the inability of …
Decoding disease: from genomes to networks to phenotypes
Interpreting the effects of genetic variants is key to understanding individual susceptibility to
disease and designing personalized therapeutic approaches. Modern experimental …
disease and designing personalized therapeutic approaches. Modern experimental …
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients
In addition to genetic predisposition, environmental and lifestyle factors contribute to the
pathogenesis of type 2 diabetes (T2D). Epigenetic changes may provide the link for …
pathogenesis of type 2 diabetes (T2D). Epigenetic changes may provide the link for …