Anti-angiogenic therapy is one of the promising strategies for many types of solid cancers.
Bevacizumab (Avastin), a recombinant humanized monoclonal antibody of vascular …

The term epigenetics is defined as heritable changes in gene expression that are not due to
alterations of the DNA sequence. In the last years, it has become more and more evident …

Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-
specific characterization of DNAm is needed to understand its role in gene regulation and its …

Abstract Canonical (H3. 1/H3. 2) and noncanonical (H3. 3) histone 3 K27M-mutant gliomas
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …

Background Recently, increasing evidence shows that long noncoding RNAs (lncRNAs)
play a significant role in human tumorigenesis. However, the function of lncRNAs in human …

The Bromodomain and Extra-Terminal Domain (BET) family of proteins is characterized by
the presence of two tandem bromodomains and an extra-terminal domain. The mammalian …

Glioblastoma multiforme (GBM) is the most common and aggressive malignant adult primary
brain tumor. Despite surgical resection followed by radiotherapy and chemotherapy, the …

Recently, long non-coding RNAs (lncRNAs) have been shown to have important regulatory
roles in human cancer biology. In our study, we found that lncRNA CCAT1, whose …

Recently, a novel class of transcripts, long non-coding RNAs (lncRNAs), is being identified
at a rapid pace. These RNAs have critical roles in diverse biological processes, including …

Abnormal epigenetic regulation has been implicated in oncogenesis. We report here the
identification of somatic mutations by exome sequencing in acute monocytic leukemia, the …