While insomnia is the second most common mental disorder, progress in our understanding
of underlying neurobiological mechanisms has been limited. The present review addresses …

Since ancient times it is known that melancholia and sleep disturbances co-occur. The
introduction of polysomnography into psychiatric research confirmed a disturbance of sleep …

Sleep is thought to be restorative to brain energy homeostasis, but it is not clear how this is
achieved. We show here that Drosophila glia exhibit a daily cycle of glial mitochondrial …

INTRODUCTION In the absence of sensory inputs, the brain produces structured patterns of
activity, which can be as large as or larger than sensory-driven activity. Ongoing activity …

Network dynamics have been proposed as a mechanistic substrate for the information
transfer across cortical and hippocampal circuits. However, little is known about the …

How does a lack of sleep affect our brains? In contrast to the benefits of sleep, frameworks
exploring the impact of sleep loss are relatively lacking. Importantly, the effects of sleep …

A thought-provoking argument that consciousness—more widespread than previously
assumed—is the feeling of being alive, not a type of computation or a clever hack In The …

Sleep is a universal, essential biological process. It is also an invaluable window on
consciousness. It tells us that consciousness can be lost but also that it can be regained, in …

Neural activity and behavior are both notoriously variable, with responses differing widely
between repeated presentation of identical stimuli or trials. Recent results in humans and …

Vigilant attention is a major component of a wide range of cognitive performance tasks.
Vigilant attention is impaired by sleep deprivation and restored after rest breaks and (more …