Molecular pathways of major depressive disorder converge on the synapse

GR Fries, VA Saldana, J Finnstein, T Rein - Molecular Psychiatry, 2023 - nature.com
Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder

AJ Cutler, GW Mattingly, V Maletic - Translational Psychiatry, 2023 - nature.com
The pathophysiology of major depressive disorder (MDD) is thought to result from impaired
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …

Individual‐level brain morphological similarity networks: Current methodologies and applications

M Cai, J Ma, Z Wang, Y Zhao, Y Zhang… - CNS Neuroscience …, 2023 - Wiley Online Library
Aims The human brain is an extremely complex system in which neurons, clusters of
neurons, or regions are connected to form a complex network. With the development of …

White matter dysfunction in psychiatric disorders is associated with neurotransmitter and genetic profiles

GJ Ji, J Sun, Q Hua, L Zhang, T Zhang, T Bai… - Nature Mental …, 2023 - nature.com
Functional changes of white matter are largely unexplored in patients with psychiatric
disorders. This study examined white matter dysfunctions common in four major psychiatric …

Macroscale connectome topographical structure reveals the biomechanisms of brain dysfunction in Alzheimer's disease

K Zhao, D Wang, D Wang, P Chen, Y Wei, L Tu… - Science …, 2024 - science.org
The intricate spatial configurations of brain networks offer essential insights into
understanding the specific patterns of brain abnormalities and the underlying biological …

Transcriptomic decoding of regional cortical vulnerability to major depressive disorder

J Zhu, X Chen, B Lu, XY Li, ZH Wang, LP Cao… - Communications …, 2024 - nature.com
Previous studies in small samples have identified inconsistent cortical abnormalities in
major depressive disorder (MDD). Despite genetic influences on MDD and the brain, it is …

Structural MRI of brain similarity networks

I Sebenius, L Dorfschmidt, J Seidlitz… - Nature Reviews …, 2024 - nature.com
Recent advances in structural MRI analytics now allow the network organization of
individual brains to be comprehensively mapped through the use of the biologically …

Regional radiomics similarity networks reveal distinct subtypes and abnormality patterns in mild cognitive impairment

K Zhao, Q Zheng, M Dyrba, T Rittman, A Li… - Advanced …, 2022 - Wiley Online Library
Individuals with mild cognitive impairment (MCI) of different subtypes show distinct
alterations in network patterns. The first aim of this study is to identify the subtypes of MCI by …

Neurophysiological stratification of major depressive disorder by distinct trajectories

D Chen, X Wang, V Voon, Y Jiang, CYZ Lo… - Nature Mental …, 2023 - nature.com
Major depressive disorder (MDD) has been characterized by structural abnormalities of
multiple brain regions. Nevertheless, little is known about the underlying neuropathological …

[HTML][HTML] Imaging transcriptomics of brain disorders

A Arnatkeviciute, BD Fulcher, MA Bellgrove… - … Psychiatry Global Open …, 2022 - Elsevier
Noninvasive neuroimaging is a powerful tool for quantifying diverse aspects of brain
structure and function in vivo, and it has been used extensively to map the neural changes …