Circadian rhythms play an influential role in nearly all aspects of physiology and behavior in
the vast majority of species on Earth. The biological clockwork that regulates these rhythms …

Throughout the industrialized world, nearly one in five employees works some form of
nontraditional shift. Such shift work is associated with numerous negative health …

Key points Exercise elicits circadian phase‐shifting effects, but additional information is
needed. The phase–response curve describing the magnitude and direction of circadian …

A common feature of aging is the advance of the timing of sleep to earlier hours, 1–7 often
earlier than desired. 8–10 The sleep of older people is also characterized by an increased …

Light around twilight provides the primary entrainment signal for circadian rhythms. Here we
review the mechanisms and responses of the mouse and human circadian systems to light …

Context: Late adolescence is marked by a delay in sleep timing, which is partly driven by a
delay shift of the circadian timing system. This study examined whether the sensitivity of the …

The circadian system in animals and humans, being near but not exactly 24 hours in cycle
length, must be reset on a daily basis to remain in synchrony with external environmental …

Humans are a diurnal species usually exposed to light while engaged in cognitive tasks.
Light not only guides performance on these tasks through vision but also exerts non-visual …

Melatonin, a pineal gland synthesized neurohormone is known as a multifunctioning
pleiotropic agent which has a wide range of neuroprotective role in manifold age-related …

Circadian rhythm disturbances, such as sleep disorders, are frequently seen in aging and
are even more pronounced in Alzheimer's disease (AD). Alterations in the biological clock …