Parkinson's disease dementia: a neural networks perspective

J Gratwicke, M Jahanshahi, T Foltynie - Brain, 2015 - academic.oup.com
In the long-term, with progression of the illness, Parkinson's disease dementia affects up to
90% of patients with Parkinson's disease. With increasing life expectancy in western …

Premotor and nonmotor features of Parkinson's disease

JG Goldman, R Postuma - Current opinion in neurology, 2014 - journals.lww.com
Premotor and nonmotor features of Parkinson's disease : Current Opinion in Neurology
Premotor and nonmotor features of Parkinson's disease : Current Opinion in Neurology Log in or …

Blood NfL: a biomarker for disease severity and progression in Parkinson disease

CH Lin, CH Li, KC Yang, FJ Lin, CC Wu, JJ Chieh… - Neurology, 2019 - AAN Enterprises
Objective To examine whether plasma neurofilament light chain (NfL) levels were
associated with motor and cognitive progression in Parkinson disease (PD). Methods This …

Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study

E Mak, L Su, GB Williams, MJ Firbank, RA Lawson… - Brain, 2015 - academic.oup.com
Mild cognitive impairment in Parkinson's disease is associated with progression to dementia
(Parkinson's disease dementia) in a majority of patients. Determining structural imaging …

Nucleus basalis of Meynert degeneration precedes and predicts cognitive impairment in Parkinson's disease

J Schulz, G Pagano, JA Fernández Bonfante, H Wilson… - Brain, 2018 - academic.oup.com
Currently, no reliable predictors of cognitive impairment in Parkinson's disease exist. We
hypothesized that microstructural changes at grey matter T1-weighted MRI and diffusion …

Dysfunction of the locus coeruleus–norepinephrine system and related circuitry in Parkinson's disease-related dementia

K Del Tredici, H Braak - Journal of Neurology, Neurosurgery & …, 2013 - jnnp.bmj.com
Although resting tremor, cogwheel rigidity, hypokinesia/bradykinesia and postural instability
usually dominate the clinical picture of sporadic Parkinson's disease (PD), both clinical and …

Bundle analytics, a computational framework for investigating the shapes and profiles of brain pathways across populations

BQ Chandio, SL Risacher, F Pestilli, D Bullock… - Scientific reports, 2020 - nature.com
Tractography has created new horizons for researchers to study brain connectivity in vivo.
However, tractography is an advanced and challenging method that has not been used so …

Functional brain networks and cognitive deficits in Parkinson's disease

HC Baggio, R Sala‐Llonch, B Segura… - Human brain …, 2014 - Wiley Online Library
Graph‐theoretical analyses of functional networks obtained with resting‐state functional
magnetic resonance imaging (fMRI) have recently proven to be a useful approach for the …

Sequence of clinical and neurodegeneration events in Parkinson's disease progression

NP Oxtoby, LA Leyland, LM Aksman, GEC Thomas… - Brain, 2021 - academic.oup.com
Dementia is one of the most debilitating aspects of Parkinson's disease. There are no
validated biomarkers that can track Parkinson's disease progression, nor accurately identify …

Gray matter, white matter and cerebrospinal fluid abnormalities in Parkinson's disease: A voxel-based morphometry study

CO Nyatega, L Qiang, MJ Adamu… - Frontiers in Psychiatry, 2022 - frontiersin.org
Background Parkinson's disease (PD) is a chronic neurodegenerative disorder
characterized by bradykinesia, tremor, and rigidity among other symptoms. With a 70 …