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Pathogenesis of autoimmune disease
DS Pisetsky - Nature Reviews Nephrology, 2023 - nature.com
Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …
and T cell reactivity to normal constituents of the host. These diseases occur widely and …
The role of platelets in immune-mediated inflammatory diseases
Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …
Pathogenesis of systemic lupus erythematosus: risks, mechanisms and therapeutic targets
Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …
Toll-like receptor 4 (TLR4): new insight immune and aging
TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4
not only engages with exogenous ligands at the cellular membrane's surface but also …
not only engages with exogenous ligands at the cellular membrane's surface but also …
Decoding Toll-like receptors: Recent insights and perspectives in innate immunity
Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune
system and are the first line of host defense against microbial pathogens by recognizing …
system and are the first line of host defense against microbial pathogens by recognizing …
Systemic lupus erythematosus pathogenesis: interferon and beyond
Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
Glomerulonephritis: immunopathogenesis and immunotherapy
Abstract 'Glomerulonephritis'(GN) is a term used to describe a group of heterogeneous
immune-mediated disorders characterized by inflammation of the filtration units of the kidney …
immune-mediated disorders characterized by inflammation of the filtration units of the kidney …
The conne**on between sex and immune responses
There are notable sex-based differences in immune responses to pathogens and self-
antigens, with female individuals exhibiting increased susceptibility to various autoimmune …
antigens, with female individuals exhibiting increased susceptibility to various autoimmune …
The immunology of systemic lupus erythematosus
Understanding the pathogenesis and clinical manifestations of systemic lupus
erythematosus (SLE) has been a great challenge. Reductionist approaches to understand …
erythematosus (SLE) has been a great challenge. Reductionist approaches to understand …
IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial
L Ackerman, G Acloque, S Bacchelli, H Schwartz… - Nature Medicine, 2023 - nature.com
Toll-like receptor–driven and interleukin-1 (IL-1) receptor–driven inflammation mediated by
IL-1 receptor–associated kinase 4 (IRAK4) is involved in the pathophysiology of hidradenitis …
IL-1 receptor–associated kinase 4 (IRAK4) is involved in the pathophysiology of hidradenitis …