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[HTML][HTML] Cyanine conjugates in cancer theranostics
Cyanine is a meritorious fluorogenic core for the construction of fluorescent probes and its
phototherapeutic potential has been enthusiastically explored as well. Alternatively, the …
phototherapeutic potential has been enthusiastically explored as well. Alternatively, the …
Hows and whys of tumor-seeking dyes
Conspectus Active targeting uses molecular fragments that bind receptors overexpressed on
cell surfaces to deliver cargoes, and this selective delivery to diseased over healthy tissue is …
cell surfaces to deliver cargoes, and this selective delivery to diseased over healthy tissue is …
Novel sulfonyl thiazolyl-hydrazone derivatives as EGFR inhibitors: Design, synthesis, biological evaluation and molecular docking studies
TA Farghaly, EMH Abbas, AM Al-Soliemy, R Sabour… - Bioorganic …, 2022 - Elsevier
New hydrazonoyl-sulfonylthiazoles were designed and synthesized as EGFR inhibitors. The
new sulfonylthiazole derivatives were assessed in vitro to measure their effect on EGFR …
new sulfonylthiazole derivatives were assessed in vitro to measure their effect on EGFR …
Small molecules and conjugates as theranostic agents
S Pratihar, KK Bhagavath, T Govindaraju - RSC Chemical Biology, 2023 - pubs.rsc.org
Theranostics, the integration of therapy and diagnostics into a single entity for the purpose of
monitoring disease progression and treatment response. Diagnostics involves identifying …
monitoring disease progression and treatment response. Diagnostics involves identifying …
Heptamethine cyanine dye mediated drug delivery: hype or hope
PJ Choi, TIH Park, E Cooper, M Dragunow… - Bioconjugate …, 2020 - ACS Publications
This review covers the application of heptamethine cyanine dye (HMCD) mediated drug
delivery. A relatively small number of HMCDs possess tumor targeting abilities, and this has …
delivery. A relatively small number of HMCDs possess tumor targeting abilities, and this has …
Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes
AR Nödling, EM Mills, X Li, D Cardella… - Chemical …, 2020 - pubs.rsc.org
Organelle-specific delivery systems are of significant clinical interest. We demonstrate the
use of common cyanine dyes Cy3 and Cy5 as vectors for targeting and delivering cargoes to …
use of common cyanine dyes Cy3 and Cy5 as vectors for targeting and delivering cargoes to …
Near‐Infrared Fluorophores Based on Heptamethine Cyanine Dyes: From Their Synthesis and Photophysical Properties to Recent Optical Sensing and Bioimaging …
NG Medeiros, CA Braga, VS Câmara… - Asian Journal of …, 2022 - Wiley Online Library
This review summarizes diverse synthetic methodologies to prepare a wide range of
heptamethine cyanine dyes, including symmetrical, unsymmetrical, and meso‐substituted …
heptamethine cyanine dyes, including symmetrical, unsymmetrical, and meso‐substituted …
[HTML][HTML] Recent advances in construction of small molecule-based fluorophore-drug conjugates
As a powerful tool to advance drug discovery, molecular imaging may provide new insights
into the process of drug effect and therapy at cellular and molecular levels. When compared …
into the process of drug effect and therapy at cellular and molecular levels. When compared …
[PDF][PDF] The use of heptamethine cyanine dyes as drug-conjugate systems in the treatment of primary and metastatic brain tumors
Effective cancer therapeutics for brain tumors must be able to cross the blood-brain barrier
(BBB) to reach the tumor in adequate quantities and overcome the resistance conferred by …
(BBB) to reach the tumor in adequate quantities and overcome the resistance conferred by …
TrkC-targeted kinase inhibitors and PROTACs
B Zhao, K Burgess - Molecular pharmaceutics, 2019 - ACS Publications
A small molecule motif (IY–IY), which binds the tropomyosin receptor kinase C (TrkC), was
used to deliver the promiscuous kinase inhibitor (KI) dasatinib into breast cancer …
used to deliver the promiscuous kinase inhibitor (KI) dasatinib into breast cancer …