Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most abundantly used classes
among therapeutic agents in medicine. NSAIDs inhibit the enzyme cyclooxygenase (COX) …

Due to its important biological and pharmacological properties, in the field of medicinal
chemistry and drug discovery, the N-acylhydrazone motif has shown to be extremely …

Novel N-acylhydrazone derivatives from acridone have been synthesized by condensation
of acridone acetohydrazide and various aldehyde. The novel acylhydrazones were tested …

Diabetes mellitus (DM) has prevailed as a chronic health condition and has become a
serious global health issue due to its numerous consequences and high prevalence. We …

A series of thirty-two isoniazid derivatives have been evaluated for their activity against four
human cancer cell lines with potent cytotoxicity (IC50 ranging from 0.61 to 3.36 μg/mL). The …

Two novel series derived from nicotinic acid were synthesized and evaluated for their
inhibitory activity against cyclooxygenases COX-1 and COX-2, and their selectivity indices …

In this study, the synthesis, anti-inflammatory and analgesic activities of eight new 5-thioalkyl-
1, 3-diaryl-1, 2, 4-triazole derivatives were reported. For the anti-inflammatory study, the …

Xanthenone based hydrazone derivatives (5a–n) have been synthesized as potential α-
glucosidase inhibitors. All synthesized compounds (5a–n) are characterized by their FTIR …

Iridium-catalyzed C–H alkylation of 3-carbonyl-2-(alkylamino) pyridines via secondary sp3 C–
H activation adjacent to the nitrogen atom, with terminal alkenes proceeded to give the …

New tilomisole-based benzimidazothiazole derivatives were designed and synthesized in
this work. Their anti-inflammatory activity was assessed through the in vivo carrageenan rat …