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Mechanisms of hypoxia signalling: new implications for nephrology
Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of
the classical physiological responses to hypoxia, led to the discovery of human oxygen …
the classical physiological responses to hypoxia, led to the discovery of human oxygen …
2-Oxoglutarate-dependent oxygenases
2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range
of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations …
of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations …
Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2
Adipose tissue macrophage (ATM) inflammation is involved with meta-inflammation and
pathology of metabolic complications. Here we report that in adipocytes, elevated lactate …
pathology of metabolic complications. Here we report that in adipocytes, elevated lactate …
Engineering hydroxylase activity, selectivity, and stability for a scalable concise synthesis of a key intermediate to belzutifan
Biocatalytic oxidations are an emerging technology for selective C− H bond activation. While
promising for a range of selective oxidations, practical use of enzymes catalyzing aerobic …
promising for a range of selective oxidations, practical use of enzymes catalyzing aerobic …
The EGLN-HIF O2-sensing system: multiple inputs and feedbacks
The EGLN (also called PHD) prolyl hydroxylase enzymes and their canonical targets, the
HIFα subunits, represent the core of an ancient oxygen-monitoring machinery used by …
HIFα subunits, represent the core of an ancient oxygen-monitoring machinery used by …
Hypoxia signaling in cancer: Implications for therapeutic interventions
Hypoxia is a persistent physiological feature of many different solid tumors and a key driver
of malignancy, and in recent years, it has been recognized as an important target for cancer …
of malignancy, and in recent years, it has been recognized as an important target for cancer …
The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia
Acute myeloid leukemia (AML) is a largely incurable disease, for which new treatments are
urgently needed. While leukemogenesis occurs in the hypoxic bone marrow, the therapeutic …
urgently needed. While leukemogenesis occurs in the hypoxic bone marrow, the therapeutic …
Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials
Inhibition of the human 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl
hydroxylases (human PHD1–3) causes upregulation of HIF, thus promoting erythropoiesis …
hydroxylases (human PHD1–3) causes upregulation of HIF, thus promoting erythropoiesis …
The genomics and genetics of oxygen homeostasis
GL Semenza - Annual review of genomics and human genetics, 2020 - annualreviews.org
Human survival is dependent upon the continuous delivery of O2 to each cell in the body in
sufficient amounts to meet metabolic requirements, primarily for ATP generation by oxidative …
sufficient amounts to meet metabolic requirements, primarily for ATP generation by oxidative …
Carbon–fluorine bond cleavage mediated by metalloenzymes
Fluorochemicals are a widely distributed class of compounds and have been utilized across
a wide range of industries for decades. Given the environmental toxicity and adverse health …
a wide range of industries for decades. Given the environmental toxicity and adverse health …