Structural and Functional Aspects of the Neurodevelopmental Gene NR2F1: From Animal Models to Human Pathology

C Tocco, M Bertacchi, M Studer - Frontiers in Molecular Neuroscience, 2021 - frontiersin.org
The assembly and maturation of the mammalian brain result from an intricate cascade of
highly coordinated developmental events, such as cell proliferation, migration, and …

Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases

PD Talukdar, U Chatterji - Signal Transduction and Targeted Therapy, 2023 - nature.com
Specific cell states in metazoans are established by the symphony of gene expression
programs that necessitate intricate synergic interactions between transcription factors and …

The impact of maternal immune activation on embryonic brain development

F McEwan, JD Glazier, R Hager - Frontiers in Neuroscience, 2023 - frontiersin.org
The adult brain is a complex structure with distinct functional sub-regions, which are
generated from an initial pool of neural epithelial cells within the embryo. This transition …

[HTML][HTML] Disruption of the gene regulatory programme in neurodevelopmental disorders

A Griffin, A Mahesh, VK Tiwari - Biochimica et Biophysica Acta (BBA)-Gene …, 2022 - Elsevier
Cortical development consists of a series of synchronised events, including fate transition of
cortical progenitors, neuronal migration, specification and connectivity. It is becoming clear …

Gut microbiota-induced microRNA-206-3p increases anxiety-like behaviors by inhibiting expression of Cited2 and STK39

Q Li, J Zhang, Z Gao, Y Zhang, J Gu - Microbial Pathogenesis, 2023 - Elsevier
Background Anxiety disorder is highly prevalent worldwide and represents a chronic and
functionally disabling condition, with high levels of psychological stress characterized by …

miR-409-3p represses Cited2 to refine neocortical layer V projection neuron identity

NR Wagner, A Sinha, V Siththanandan… - Frontiers in …, 2022 - frontiersin.org
The evolutionary emergence of the corticospinal tract and corpus callosum are thought to
underpin the expansion of complex motor and cognitive abilities in mammals. Molecular …

Citalopram exposure of hESCs during neuronal differentiation identifies dysregulated genes involved in neurodevelopment and depression

M Spildrejorde, M Leithaug, A Samara… - Frontiers in Cell and …, 2024 - frontiersin.org
Selective serotonin reuptake inhibitors (SSRIs), including citalopram, are widely used
antidepressants during pregnancy. However, the effects of prenatal exposure to citalopram …

Characterization and manipulation of Corticothalamic neurons in associative cortices using Syt6‐Cre transgenic mice

LO Vaasjo, X Han, AN Thurmon… - Journal of …, 2022 - Wiley Online Library
Corticothalamic interactions between associative cortices and higher order thalamic nuclei
are involved in high‐cognitive functions such as decision‐making and working memory …

Zmiz1 is a novel regulator of brain development associated with autism and intellectual disability

R KC, AS Tiemroth, AN Thurmon, SM Meadows… - Frontiers in …, 2024 - frontiersin.org
Neurodevelopmental disorders (NDDs) are a class of pathologies arising from perturbations
in brain circuit formation and maturation with complex etiological triggers often classified as …

Loss of Zmiz1 in mice leads to impaired cortical development and autistic-like behaviors

R KC, NR Patel, AN Thurmon, MG Lorino, AS Tiemroth… - bioRxiv, 2024 - biorxiv.org
De novo mutations in transcriptional regulators are emerging as key risk factors contributing
to the etiology of neurodevelopmental disorders. Human genetic studies have recently …