GelMA-based bioactive hydrogel scaffolds with multiple bone defect repair functions: therapeutic strategies and recent advances

B Zhou, X Jiang, X Zhou, W Tan, H Luo, S Lei… - Biomaterials …, 2023 - spj.science.org
Currently, the clinical treatment of critical bone defects attributed to various causes remains
a great challenge, and repairing these defects with synthetic bone substitutes is the most …

Leveraging the recent advancements in GelMA scaffolds for bone tissue engineering: an assessment of challenges and opportunities

N Mamidi, F Ijadi, MH Norahan - Biomacromolecules, 2023 - ACS Publications
The field of bone tissue engineering has seen significant advancements in recent years.
Each year, over two million bone transplants are performed globally, and conventional …

Diabetic bone regeneration with nanoceria-tailored scaffolds by recapitulating cellular microenvironment: activating integrin/TGF-β co-signaling of MSCs while …

RK Singh, DS Yoon, N Mandakhbayar, C Li, AG Kurian… - Biomaterials, 2022 - Elsevier
Regenerating defective bone in patients with diabetes mellitus remains a significant
challenge due to high blood glucose level and oxidative stress. Here we aim to tackle this …

Multifunctional molybdenum-based nanoclusters engineered gelatin methacryloyl as in situ photo-cross-linkable hybrid hydrogel dressings for enhanced wound …

AG Kurian, N Mandakhbayar, RK Singh… - … Applied Materials & …, 2024 - ACS Publications
Skin injuries and wounds present significant clinical challenges, necessitating the
development of advanced wound dressings for efficient wound healing and tissue …

Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

AG Kurian, RK Singh, V Sagar, JH Lee, HW Kim - Nano-Micro Letters, 2024 - Springer
Inflammatory skin disorders can cause chronic scarring and functional impairments, posing
a significant burden on patients and the healthcare system. Conventional therapies, such as …

GelMA and biomimetic culture allow the engineering of mineralized, adipose, and tumor tissue human microenvironments for the study of advanced prostate cancer in …

A Bessot, J Gunter, D Waugh… - Advanced …, 2023 - Wiley Online Library
Increasing evidence shows bone marrow (BM)‐adipocytes as a potentially important
contributor in prostate cancer (PCa) bone metastases. However, a lack of relevant models …

[HTML][HTML] Multifunctional dendrimer@ nanoceria engineered GelMA hydrogel accelerates bone regeneration through orchestrated cellular responses

AG Kurian, N Mandakhbayar, RK Singh, JH Lee… - Materials Today Bio, 2023 - Elsevier
Bone defects in patients entail the microenvironment that needs to boost the functions of
stem cells (eg, proliferation, migration, and differentiation) while alleviating severe …

Roles of neutrophil reactive oxygen species (ROS) generation in organ function impairment in sepsis

J Lu, J Liu, A Li - Journal of Zhejiang University-SCIENCE B, 2022 - Springer
Sepsis is a condition of severe organ failure caused by the maladaptive response of the host
to an infection. It is a severe complication affecting critically ill patients, which can progress …

Nanoceria-GO-intercalated multicellular spheroids revascularize and salvage critical ischemic limbs through anti-apoptotic and pro-angiogenic functions

O Bayaraa, K Dashnyam, RK Singh, N Mandakhbayar… - Biomaterials, 2023 - Elsevier
Critical limb ischemia (CLI) is a serious form of peripheral arterial disease that involves
severe blockage of blood flow in lower extremities, often leading to foot necrosis and limb …