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The heterocellular heart: identities, interactions, and implications for cardiology
The heterocellular nature of the heart has been receiving increasing attention in recent
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …
[HTML][HTML] Advances in human organs-on-chips and applications for drug screening and personalized medicine
The limitations of conventional animal tests and two-dimensional cell culture hinder their
advancement in fundamental research and clinical/translational applications. As an …
advancement in fundamental research and clinical/translational applications. As an …
Preclinical models of cardiac disease: a comprehensive overview for clinical scientists
For recent decades, cardiac diseases have been the leading cause of death and morbidity
worldwide. Despite significant achievements in their management, profound understanding …
worldwide. Despite significant achievements in their management, profound understanding …
Strain sensor on a chip for quantifying the magnitudes of tensile stress on cells
During cardiac development, mechanotransduction from the in vivo microenvironment
modulates cardiomyocyte growth in terms of the number, area, and arrangement …
modulates cardiomyocyte growth in terms of the number, area, and arrangement …
Vincristine attenuates isoprenaline-induced cardiac hypertrophy in male Wistar rats via suppression of ROS/NO/NF-қB signalling pathways
Vincristine (VCR), a vinca alkaloid with anti-tumor and anti-oxidant properties, is acclaimed
to possess cardioprotective action. However, the molecular mechanism underlying this …
to possess cardioprotective action. However, the molecular mechanism underlying this …
Biomimetic cardiac tissue culture model (CTCM) to emulate cardiac physiology and pathophysiology ex vivo
There is need for a reliable in vitro system that can accurately replicate the cardiac
physiological environment for drug testing. The limited availability of human heart tissue …
physiological environment for drug testing. The limited availability of human heart tissue …
Myocardial fatigue: a mechano-energetic concept in heart failure
Abstract Purpose of Review This review combines existing mechano-energetic principles to
provide a refreshing perspective in heart failure (HF) and examine if the phenomenon of …
provide a refreshing perspective in heart failure (HF) and examine if the phenomenon of …
Chemical and mechanical activation of resident cardiac macrophages in the living myocardial slice ex vivo model
Resident cardiac macrophages (rcMACs) are among the most abundant immune cells in the
heart. Plasticity and activation are hallmarks of rcMACs in response to changes in the …
heart. Plasticity and activation are hallmarks of rcMACs in response to changes in the …
Striated muscle proteins are regulated both by mechanical deformation and by chemical post-translational modification
All cells sense force and build their cytoskeleton to optimize function. How is this achieved?
Two major systems are involved. The first is that load deforms specific protein structures in a …
Two major systems are involved. The first is that load deforms specific protein structures in a …
[HTML][HTML] Cardiac organoids to model and heal heart failure and cardiomyopathies
Cardiac tissue engineering aims at creating contractile structures that can optimally
reproduce the features of human cardiac tissue. These constructs are becoming valuable …
reproduce the features of human cardiac tissue. These constructs are becoming valuable …