Development and challenges of antimicrobial peptides for therapeutic applications
More than 3000 antimicrobial peptides (AMPs) have been discovered, seven of which have
been approved by the US Food and Drug Administration (FDA). Now commercialized, these …
been approved by the US Food and Drug Administration (FDA). Now commercialized, these …
[HTML][HTML] The gramicidin ion channel: a model membrane protein
The linear peptide gramicidin forms prototypical ion channels specific for monovalent
cations and has been extensively used to study the organization, dynamics and function of …
cations and has been extensively used to study the organization, dynamics and function of …
Predicting slow structural transitions in macromolecular systems: Conformational flooding
H Grubmüller - Physical Review E, 1995 - APS
We present a method to predict complex structural (conformational) transitions in irregular or
disordered macromolecular systems, such as proteins or glasses, at the atomic level. Our …
disordered macromolecular systems, such as proteins or glasses, at the atomic level. Our …
The biophysics of peptide models of ion channels
MS Sansom - Progress in biophysics and molecular biology, 1991 - Elsevier
1. General Introduction 2. An Introduction to Ion Channels (a) General properties of ion
channels (i) Fundamental properties (ii) Planar bilayer electrophysiology (iii) Physiological …
channels (i) Fundamental properties (ii) Planar bilayer electrophysiology (iii) Physiological …
Model ion channels: gramicidin and alamethicin
Ion channels control the flux of ions across lipid bilayers in an extremely sensitive and
specific manner. From a description of selective permeability (Bernstein, 1912), made more …
specific manner. From a description of selective permeability (Bernstein, 1912), made more …
[BOOK][B] Molecular and cellular biophysics
MB Jackson - 2006 - books.google.com
Molecular and Cellular Biophysics provides advanced undergraduate and graduate
students with a foundation in the basic concepts of biophysics. Students who have taken …
students with a foundation in the basic concepts of biophysics. Students who have taken …
A lattice relaxation algorithm for three-dimensional Poisson-Nernst-Planck theory with application to ion transport through the gramicidin A channel
A lattice relaxation algorithm is developed to solve the Poisson-Nernst-Planck (PNP)
equations for ion transport through arbitrary three-dimensional volumes. Calculations of …
equations for ion transport through arbitrary three-dimensional volumes. Calculations of …
Gas-phase infrared spectroscopy of neutral peptides: Insights from the far-IR and THz domain
Gas-phase, double resonance IR spectroscopy has proven to be an excellent approach to
obtain structural information on peptides ranging from single amino acids to large peptides …
obtain structural information on peptides ranging from single amino acids to large peptides …
Mixed atomistic and coarse-grained molecular dynamics: simulation of a membrane-bound ion channel
The recently developed multiscale coarse-graining (MS-CG) method (Izvekov, S.; Voth, GAJ
Phys. Chem. B 2005, 109, 2469; J. Chem. Phys. 2005, 123, 134105) is used to build a mixed …
Phys. Chem. B 2005, 109, 2469; J. Chem. Phys. 2005, 123, 134105) is used to build a mixed …
Synthetic models of cation-conducting channels
GW Gokel, A Mukhopadhyay - Chemical Society Reviews, 2001 - pubs.rsc.org
Modern channel proteins are complex in structure and marvelous in function. The earliest
channels cannot possibly have been so complex but they must have functioned at some …
channels cannot possibly have been so complex but they must have functioned at some …