The clinical diagnosis of synucleinopathies, including Parkinson's disease (PD), dementia
with Lewy bodies (DLB), and multiple system atrophy (MSA), is challenging, especially at an …

The misfolding of proteins such as the prion protein, α-synuclein, and tau represents a key
initiating event for pathogenesis of most common neurodegenerative disorders, and its …

Prion diseases are a unique group of rare neurodegenerative disorders characterized by
tissue deposition of heterogeneous aggregates of abnormally folded protease-resistant …

Prion real‐time quaking‐induced conversion (RT‐QuIC) is an ultrasensitive assay detecting
pathological aggregates of misfolded prion protein in biospecimens. We studied 71 punch …

The peripheral nervous system (PNS) relays messages between the central nervous system
(brain and spinal cord) and the body. Despite this critical role and widespread distribution …

Prion diseases are rapidly progressive, invariably fatal, transmissible neurodegenerative
disorders associated with the accumulation of the amyloidogenic form of the prion protein in …

Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare and fatal neurodegenerative disorder
with an incidence of 1.5 to 2 cases per million population/year. The disease is caused by a …

Human prion diseases are a rare group of transmissible neurodegenerative conditions
which are classified according to their aetiology as sporadic, genetic or acquired forms …

Introduction Before the introduction of MRI diffusion-weighted images (DWI), the diagnosis of
Creutzfeldt–Jakob disease (CJD) relied upon nonspecific findings including clinical …

Background Movement disorders are frequent features of prionopathies. However, their
prevalence and onset remain poorly described. Methods We performed a systematic review …