The p53 protein is a transcription factor known as the" guardian of the genome" because of
its critical function in preserving genomic integrity. The TP53 gene is mutated in …

Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Cas9 is commonly introduced into cell lines to enable CRISPR–Cas9-mediated genome
editing. Here, we studied the genetic and transcriptional consequences of Cas9 expression …

Cancer is a leading cause of death worldwide. Targeted therapies aimed at key oncogenic
driver mutations in combination with chemotherapy and radiotherapy as well as …

The tripartite-motif (TRIM) family represents one of the largest classes of putative single
protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular …

The p53 tumor suppressor continues to be distinguished as the most frequently mutated
gene in human cancer. It is widely believed that the ability of p53 to induce senescence and …

Lineage-tracing methods have enabled characterization of clonal dynamics in complex
populations, but generally lack the ability to integrate genomic, epigenomic and …

Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …

In the context of tumor suppression, p53 is an undisputedly critical protein. Functioning
primarily as a transcription factor, p53 helps fend off the initiation and progression of tumors …

The functions of the proto-oncoprotein c-Myc and the tumor suppressor p53 in controlling
cell survival and proliferation are inextricably linked as “Yin and Yang” partners in normal …