Is early-onset cancer an emerging global epidemic? Current evidence and future implications
Over the past several decades, the incidence of early-onset cancers, often defined as
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …
Tutorial: a guide to performing polygenic risk score analyses
A polygenic score (PGS) or polygenic risk score (PRS) is an estimate of an individual's
genetic liability to a trait or disease, calculated according to their genotype profile and …
genetic liability to a trait or disease, calculated according to their genotype profile and …
PRSice-2: Polygenic Risk Score software for biobank-scale data
Background Polygenic risk score (PRS) analyses have become an integral part of
biomedical research, exploited to gain insights into shared aetiology among traits, to control …
biomedical research, exploited to gain insights into shared aetiology among traits, to control …
Epidemiological characteristics of and risk factors for breast cancer in the world
Z Momenimovahed, H Salehiniya - Breast Cancer: Targets and …, 2019 - Taylor & Francis
Aim Breast cancer is the most common cancer among women and one of the most important
causes of death among them. This review aimed to investigate the incidence and mortality …
causes of death among them. This review aimed to investigate the incidence and mortality …
The personal and clinical utility of polygenic risk scores
Initial expectations for genome-wide association studies were high, as such studies
promised to rapidly transform personalized medicine with individualized disease risk …
promised to rapidly transform personalized medicine with individualized disease risk …
Key steps for effective breast cancer prevention
Despite decades of laboratory, epidemiological and clinical research, breast cancer
incidence continues to rise. Breast cancer remains the leading cancer-related cause of …
incidence continues to rise. Breast cancer remains the leading cancer-related cause of …
Polygenic risk scores for prediction of breast cancer and breast cancer subtypes
Stratification of women according to their risk of breast cancer based on polygenic risk
scores (PRSs) could improve screening and prevention strategies. Our aim was to develop …
scores (PRSs) could improve screening and prevention strategies. Our aim was to develop …
Epidemiology of esophageal squamous cell carcinoma
CC Abnet, M Arnold, WQ Wei - Gastroenterology, 2018 - Elsevier
Esophageal squamous cell carcinoma (ESCC) accounts for about 90% of the 456,000
incident esophageal cancers each year. Regions of high incidence include Eastern to …
incident esophageal cancers each year. Regions of high incidence include Eastern to …
From GWAS to function: using functional genomics to identify the mechanisms underlying complex diseases
Genome-wide association studies (GWAS) have successfully mapped thousands of loci
associated with complex traits. These associations could reveal the molecular mechanisms …
associated with complex traits. These associations could reveal the molecular mechanisms …
BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors
A Lee, N Mavaddat, AN Wilcox, AP Cunningham… - Genetics in …, 2019 - nature.com
Purpose Breast cancer (BC) risk prediction allows systematic identification of individuals at
highest and lowest risk. We extend the Breast and Ovarian Analysis of Disease Incidence …
highest and lowest risk. We extend the Breast and Ovarian Analysis of Disease Incidence …