RNA G-quadruplexes in biology: principles and molecular mechanisms
Abstract G-quadruplexes (G4s) are extremely stable DNA or RNA secondary structures
formed by sequences rich in guanine. These structures are implicated in many essential …
formed by sequences rich in guanine. These structures are implicated in many essential …
RNA G-quadruplexes (rG4s): genomics and biological functions
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …
have been first observed decades ago. Over the years, these four-stranded structural motifs …
Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back
Abstract Guanine-quadruplexes (G4s) are non-canonical four-stranded structures that can
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …
Inhibition of RNA-binding proteins with small molecules
P Wu - Nature Reviews Chemistry, 2020 - nature.com
Protein–RNA interactions have crucial roles in various cellular activities, which, when
dysregulated, can lead to a range of human diseases. The identification of small molecules …
dysregulated, can lead to a range of human diseases. The identification of small molecules …
RNA G-quadruplexes: emerging mechanisms in disease
A Cammas, S Millevoi - Nucleic acids research, 2017 - academic.oup.com
Abstract RNA G-quadruplexes (G4s) are formed by G-rich RNA sequences in protein-coding
(mRNA) and non-coding (ncRNA) transcripts that fold into a four-stranded conformation …
(mRNA) and non-coding (ncRNA) transcripts that fold into a four-stranded conformation …
The diverse structural landscape of quadruplexes
G‐quadruplexes are secondary structures formed in G‐rich sequences in DNA and RNA.
Considerable research over the past three decades has led to in‐depth insight into these …
Considerable research over the past three decades has led to in‐depth insight into these …
Protective effect of let-7 miRNA family in regulating inflammation in diabetes-associated atherosclerosis
The let-7 miRNA family plays a key role in modulating inflammatory responses. Vascular
smooth muscle cell (SMC) proliferation and endothelial cell (EC) dysfunction are critical in …
smooth muscle cell (SMC) proliferation and endothelial cell (EC) dysfunction are critical in …
Apurinic/Apyrimidinic Endodeoxyribonuclease 1 modulates RNA G-quadruplex folding of miR-92b and controls its expression in cancer cells
In the last decade, several novel functions of the mammalian Apurinic/Apyrimidinic
Endodeoxyribonuclease 1 (APE1) have been discovered, going far beyond its canonical …
Endodeoxyribonuclease 1 (APE1) have been discovered, going far beyond its canonical …
N-methyl mesoporphyrin IX as a highly selective light-up probe for G-quadruplex DNA
A Yett, LY Lin, D Beseiso, J Miao… - Journal of porphyrins …, 2019 - World Scientific
N-methyl mesoporphyrin IX (NMM) is a water-soluble, non-symmetric porphyrin with
excellent optical properties and unparalleled selectivity for G-quadruplex (GQ) DNA. G …
excellent optical properties and unparalleled selectivity for G-quadruplex (GQ) DNA. G …
Preclinical studies for the combination of paclitaxel and curcumin in cancer therapy
Y Wei, X Pu, L Zhao - Oncology reports, 2017 - spandidos-publications.com
Cancer is one of the most common causes of death and remains the first in China and the
second in the US. The common treatments for cancer include surgery, radiation …
second in the US. The common treatments for cancer include surgery, radiation …