Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase

RJ Obaid, N Naeem, EU Mughal, MM Al-Rooqi… - RSC …, 2022 - pubs.rsc.org
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …

Novel 1, 2, 4-oxadiazole derivatives in drug discovery

K Biernacki, M Daśko, O Ciupak, K Kubiński, J Rachon… - Pharmaceuticals, 2020 - mdpi.com
Five-membered 1, 2, 4-oxadiazole heterocyclic ring has received considerable attention
because of its unique bioisosteric properties and an unusually wide spectrum of biological …

Design, synthesis, biological evaluation and molecular docking studies of novel 1H-1, 2, 3-Triazole derivatives as potent inhibitors of carbonic anhydrase …

DA Anil, BO Aydin, Y Demir, B Turkmenoglu - Journal of Molecular …, 2022 - Elsevier
Triazole compounds have garnered significant interest due to their wide range of
pharmacological activities and ease of synthesis. Click chemistry is a synthetic method …

Artificial intelligence, big data and machine learning approaches in precision medicine & drug discovery

A Nayarisseri, R Khandelwal, P Tanwar… - Current drug …, 2021 - ingentaconnect.com
Artificial Intelligence revolutionizes the drug development process that can quickly identify
potential biologically active compounds from millions of candidate within a short period. The …

An overview of 1, 2, 3-triazole-containing hybrids and their potential anticholinesterase activities

SA Khan, MJ Akhtar, U Gogoi, DU Meenakshi, A Das - Pharmaceuticals, 2023 - mdpi.com
Acetylcholine (ACh) neurotransmitter of the cholinergic system in the brain is involved in
learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline …

Recent developments in the synthesis and biological activity of acridine/acridone analogues

M Gensicka-Kowalewska, G Cholewiński… - RSC …, 2017 - pubs.rsc.org
Many people in the world struggle with cancer or bacterial, parasitic, viral, Alzheimer's and
other diseases. Therefore, many scientists seek new, more effective, more selective and less …

Triazole derivatives as inhibitors of Alzheimer's disease: current developments and structure-activity relationships

M Xu, Y Peng, L Zhu, S Wang, J Ji… - European journal of …, 2019 - Elsevier
Alzheimer's disease (AD) is a well known neurodegenerative disorder alarming millions of
people worldwide and the subsequent epidemiological statistics highlights the implication of …

Click chemistry-aided drug discovery: A retrospective and prospective outlook

R Zhao, J Zhu, X Jiang, R Bai - European Journal of Medicinal Chemistry, 2024 - Elsevier
Click chemistry has emerged as a valuable tool for rapid compound synthesis, presenting
notable advantages and convenience in the exploration of potential drug candidates. In …

Discovery of triazole-bridged aryl adamantane analogs as an intriguing class of multifunctional agents for treatment of Alzheimer's disease

G Gutti, J Leifeld, R Kakarla, NG Bajad… - European Journal of …, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive brain disorder associated with slow loss of brain
functions leading to memory failure and modest changes in behavior. The multifactorial …

Coumarin–triazole hybrids and their biological activities

YL Fan, X Ke, M Liu - Journal of Heterocyclic Chemistry, 2018 - Wiley Online Library
Hybridization is emerged as a promising strategy in the discovery of new drugs, especially
these with complimentary activities and multiple pharmacological targets that are the …