Landscape of human organoids: Ideal model in clinics and research

X Han, C Cai, W Deng, Y Shi, L Li, C Wang… - The …, 2024 - pmc.ncbi.nlm.nih.gov
In the last decade, organoid research has entered a golden era, signifying a pivotal shift in
the biomedical landscape. The year 2023 marked a milestone with the publication of …

Applications of 3D organoids in toxicological studies: a comprehensive analysis based on bibliometrics and advances in toxicological mechanisms

H Yang, S Niu, M Guo, Y Xue - Archives of Toxicology, 2024 - Springer
A mechanism exploration is an important part of toxicological studies. However, traditional
cell and animal models can no longer meet the current needs for in-depth studies of …

A Comprehensive Review on Utilizing Human Brain Organoids to Study Neuroinflammation in Neurological Disorders

AD Rubio, L Hamilton, M Bausch, M **… - Journal of Neuroimmune …, 2025 - Springer
Most current information about neurological disorders and diseases is derived from direct
patient and animal studies. However, patient studies in many cases do not allow replication …

Cardiac Disease Modeling with Engineered Heart Tissue

L Cai, R Wang, D Zhang - Human iPSC-derived Disease Models for Drug …, 2023 - Springer
The rhythmically beating heart is the foundation of life-sustaining blood flow. There are four
chambers and many different types of cell in the heart, but the twisted myofibrillar structures …

Methods for generating self-organizing human patterned heart organoids using pluripotent stem cells

B Volmert, A Aguirre - 2024 - Springer
Organoids derived from pluripotent stem cells exhibit notable similarities to organ
development in vitro. Nonetheless, cardiac organoids generated to date possess immature …

In vivo bioluminescence for the detection of the fate of pancreatic islet organoids post-transplantation

A Sun, E Kenyon, M Gudi, W Li, A Aguirre… - Type-1 Diabetes …, 2022 - Springer
Pancreatic islet transplantation is a promising cell replacement treatment for patients
afflicted with type 1 diabetes (T1D), which is an autoimmune disease resulting in the …

Organoide–der Schlüssel zu neuen Therapien für das Innenohr?

M Diensthuber, T Stöver - HNO, 2023 - Springer
Zusammenfassung Die Empfindlichkeit und die Komplexität des menschlichen Innenohrs in
Verbindung mit der fehlenden Fähigkeit zur Regeneration sind die entscheidenden Gründe …

Organoids—the key to novel therapies for the inner ear?

M Diensthuber, T Stöver - HNO, 2024 - Springer
The sensitivity and the complexity of the human inner ear in conjunction with the lack of
regenerative capacity are the main reasons for hearing loss and tinnitus. Progress in the …